ML291 - Moligand™, ≥98% , CAS No.1523437-16-2

CAS: 1523437-16-2 Cat. No.: M646804 분자식: C₁₆H₁₆ClN₃O₆S 분자량: 413.83 EC 번호: 808-922-2 PubChem CID: 52940465

GRADE & PURITY Moligand™, ≥98%

Synonyms

1523437-16-2 | MLS003940499 | AKOS037643523 | KSC-220-24-1 | KUC109671N | cl-cob-III-194 | YKC43716 | KSC-325-040 | XKMLYHZJKCRLOI-UHFFFAOYSA-N | AS-16755 | HY-101991 | N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide | SMR0026327

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

개요

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden.

Form:Solid

Specifications

동의어

1523437-16-2 | MLS003940499 | AKOS037643523 | KSC-220-24-1 | KUC109671N | cl-cob-III-194 | YKC43716 | KSC-325-040 | XKMLYHZJKCRLOI-UHFFFAOYSA-N | AS-16755 | HY-101991 | N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide | SMR0026327

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

ML291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and re

보관 조건

Store at 2-8°C,Argon charged

배송

Wet ice

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등급

Moligand™

작업 유형

ACTIVATOR

순수함

≥98%

이름과 식별자

정식 스마일

C1CN(CCC1Cl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC=C(O3)[N+](=O)[O-]

IUPAC Name

N-[4-(4-chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide

InChIKey

XKMLYHZJKCRLOI-UHFFFAOYSA-N

INCHI

1S/C16H16ClN3O6S/c17-11-7-9-19(10-8-11)27(24,25)13-3-1-12(2-4-13)18-16(21)14-5-6-15(26-14)20(22)23/h1-6,11H,7-10H2,(H,18,21)

이성체 SMILES

C1CN(CCC1Cl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC=C(O3)[N+](=O)[O-]

WGK 독일

3

PubChem CID

52940465

분자량

413.83

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • 분류 Benzene and substituted derivatives
      • Subclass Anilides
        • Level5 Aromatic anilides
          • Level6 Furanilides
            • Level7 2-furanilides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• 분류: Benzene and substituted derivatives
• Subclass: Anilides
• Intermediate Tree Nodes: Aromatic anilides - Furanilides
• Direct Parent: 2-furanilides
• Alternative Parents: Benzenesulfonamides Benzenesulfonyl compounds 2-heteroaryl carboxamides Furoic acid and derivatives Nitroaromatic compounds Nitrofurans Piperidines Organosulfonamides Sulfonyls Heteroaromatic compounds Secondary carboxylic acid amides Organic oxoazanium compounds Oxacyclic compounds Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Organic zwitterions Organic salts Organic oxides Organooxygen compounds Organopnictogen compounds Hydrocarbon derivatives Alkyl chlorides Organochlorides Organonitrogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: 2-furanilide - Benzenesulfonamide - Benzenesulfonyl group - 2-heteroaryl carboxamide - Furoic acid or derivatives - Nitroaromatic compound - 2-nitrofuran - Piperidine - Organosulfonic acid amide - Furan - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Heteroaromatic compound - Carboxamide group - Organic nitro compound - C-nitro compound - Secondary carboxylic acid amide - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Oxacycle - Azacycle - Carboxylic acid derivative - Organic oxoazanium - Hydrocarbon derivative - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organopnictogen compound - Organohalogen compound - Organic oxygen compound - Alkyl halide - Alkyl chloride - Organic oxide - Organic nitrogen compound - Organic zwitterion - Organic salt - Aromatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as 2-furanilides. These are aromatic heterocyclic compounds contaning a furan ring that is substituted at the 2-position with an anilide.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

DDIT3 Tchem DNA damage-inducible transcript 3 protein (1 Activities)

Discover Target: DDIT3

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

Discover Target: SLC6A3

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IMR-90 (216 Activities)

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XBP1 Tchem X-box-binding protein 1 (1001 Activities)

Discover Target: XBP1

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관련 대상(비인간)

Trypanosoma brucei (78846 Activities)

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Mus musculus (284745 Activities)

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MEF (1005 Activities)

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Plasma (328 Activities)

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Ddit3 DNA damage-inducible transcript 3 protein (953 Activities)

Discover Target: Ddit3

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Liver microsome (341 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO : ≥ 50 mg/mL (120.82 mM)
• 감도: Air sensitive
• 분자량: 413.800 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 413.045 Da
• Monoisotopic Mass: 413.045 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 27
• Formal Charge: 0
• Complexity: 648.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

자주 묻는 질문

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1523437-16-2, the molecular formula is C16H16ClN3O6S, and the molecular weight is 413.83 g/mol. InChIKey XKMLYHZJKCRLOI-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.