Determine the necessary mass, volume, or concentration for preparing a solution.
MMV009085 , CAS No.298217-59-1
주문 가능
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
MMV009085 is a potent Pf HT1 ( Plasmodium falciparum hexose transporter) -specific inhibitor and a potential anti-malarial agent. MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC 50 : 2.6 μM in glucose uptake assay) and growth of the parasites (EC 50 : 1.23±0.04 μM against 3D7 ).
In Vitro
MMV009085 inhibits the transport activity of PfHT-1 with an IC 50 of 212 ± 39 μM, the EC 50 values of MMV009085 in the parasite growth inhibition assay are 1.23 ± 0.04 μM against 3D7 and 0.720 ± 0.05 μM against Dd2 . MMV009085 displays significant cytotoxicity with CC 50 values of 2.46 ± 0.03 μM and 1.92 ± 0.85 μM for HEK293T and HepG2 cells, respectively. MMV009085 shows IC 50 of 2.6 μM in glucose uptake assay in freed parasites, MMV009085 shows an EC50 of 0.987 μM for inhibition of growth of P. falciparum strain 3D7 in in vitro growth inhibition assay, this compound acts through PfHT blockage to inhibit parasite growth ( EC 50 =0.795 μM).. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Specifications
생화학 및 생리적 메커니즘
MMV009085 is a potent Pf HT1 ( Plasmodiumxa0falciparumxa0hexose transporter) -specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC 50 :
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
작업 유형
INHIBITOR
이름과 식별자
| 분자량 | 410.42 |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
솔루션 계산기
리뷰
고객 리뷰
자주 묻는 질문
How should this product be stored?
Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.
How is this product shipped?
This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 298217-59-1, the molecular formula is C22H22N2O6, and the molecular weight is 410.42 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
Remind me later
Products are supplied to verified businesses, institutions, and qualified professionals for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
Copyright © 2023–present Aladdin Scientific Corp. All rights reserved.