Motixafortide(TFA) - Moligand™, ≥98% , CAS No.664334-36-5(free base)

CAS: 664334-36-5(free base) Cat. No.: M414450 분자식: C₉₇H₁₄₄FN₃₃O₁₉S₂(free base) 분자량: 2159.52(free base)

GRADE & PURITY Moligand™, ≥98%

Synonyms

BKT140 (TFA) | BL-8040(TFA) | TF14016(TFA

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Information

Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist ofCXCR4with IC50 of ～1 nM. BL-8040 induces theapoptosisof AML blasts by down-regulatingERK,BCL-2,MCL-1andcyclin-D1via altered miR-15a/16-1 expression.

Targets

ERK ; Bcl-2 ; MCL-1 ; cyclin-D1 ; CXCR4 (Cell-free assay) ; 1 nM

In vitro

Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro. This apoptosis is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways.

In vivo

BL-8040 induces the apoptosis of AML cells in vivo. Treatment with a BCL-2 inhibitor induces apoptosis and acts together with BL-8040 to enhance cell death. BL-8040 also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo.

Cell Research(from reference)

Cell lines：The leukemic cell lines (MV4-11, THP-1, U937, HL-60) 

Concentrations：0.1 μM, 1 μM, 10 μM, 20 μM 

Incubation Time：24 h, 48 h 

Specifications

동의어

BKT140 (TFA) | BL-8040(TFA) | TF14016(TFA

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ～1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expr

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

순수함

≥98%

이름과 식별자

분자량

2159.52(free base)

관련 대상(인간)

CXCR4 Tclin C-X-C chemokine receptor type 4 (0 Activities)

Discover Target: CXCR4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro Water: 100 mg/mL (46.3 mM)