MPO-IN-1 - ≥99% , CAS No.2471981-21-0

CAS: 2471981-21-0 Cat. No.: M648657 분자식: C₂₄H₂₁ClN₄ 분자량: 400.90

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase ( MPO ). MPO-IN-1 has IC 50 s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation

In Vivo

MPO-IN-1 (compound 2) (5 and 90 mg/kg; p.o.; four hours post-Zymosan A administration) significantly reduces MPO activity in a mouse peritonitis model of acute inflammation . Mouse pharmacokinetic parameter of MPO-IN-1 . Dose V ss (L/kg) T 1/2 (h) AUC inf (nM•h) p.o. C max (nM) p.o. PPB (%) F (%) 1/10 mg/kg i.v./p.o. 9.8 2.6 2486 502 99.6 61 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6J mice (mouse peritonitis model of acute inflammation) Dosage: 5 and 90 mg/kg Administration: p.o. (four hours post-Zymosan A administration) Result: Resulted in a ~50% reduction in the MPO activity at 90 mg/kg.

Form:Solid

IC50& Target:2.6 μM (in plasma MPO assay),0.12 μM (in fluorescent MPO peroxidation assay)

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase ( MPO ). MPO-IN-1 has IC 50 s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse mo

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

• 분자량: 400.90

화학 및 물리적 특성

• 용해성: DMSO : 200 mg/mL (498.88 mM; ultrasonic and warming and heat to 60°C)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2471981-21-0, the molecular formula is C24H21ClN4, and the molecular weight is 400.90 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.