MT1 - 10mM in DMSO , CAS No.2060573-82-0

CAS: 2060573-82-0 Cat. No.: M656493 분자식: C₅₄H₆₆Cl₂N₁₀O₉S₂ 분자량: 1134.20 PubChem CID: 122172644

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1).

In Vitro

MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MV4;11 cells. Concentration: 100 nM. Incubation Time: 24 h. Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.

In Vivo

MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1 . MT1 exhibits terminal t 1/2 of 2.70 h in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Leukemia xenograft models . Dosage: 44.2 and 22.1 µmol/kg. Administration: Intraperitoneally for 14 subsequent days. Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1).

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

PubChem CID

122172644

분자량

1134.20

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2060573-82-0, the molecular formula is C54H66Cl2N10O9S2, and the molecular weight is 1134.20 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.