Naringin - Moligand™, 10mM in DMSO , Inhibitor of OATP1A2, CAS No.10236-47-2, Inhibitor of OATP1A2

CAS: 10236-47-2 Cat. No.: N409023 분자식: C₂₇H₃₂O₁₄ 분자량: 580.53 Beilstein Registry Number: 102012 EC 번호: 233-566-4

등급 & 순도 Moligand™, 10mM in DMSO

Synonyms

Naringoside | 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
In vitro

Naringin is a flavanone glycoside, which gives the grapefruit juice its bitter taste. Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin is also an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis. In addition, Naringin reduces diabetes-induced neuropathy in rats.

In vivo

LD50: Mice 1650mg/kg.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

사양

동의어

Naringoside | 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Naringin (Naringoside) is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

Inhibitor of OATP1A2

이름과 식별자

이성체 SMILES

C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O

WGK 독일

3

RTECS

QN6340000

분자량

580.53

Beilstein

102012

Reaxy-Rn

25075985

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25075985&ln=

관련 대상(인간)

SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (0 Activities)

Discover Target: SLCO1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 56 mg/mL (197.0 mM); Ethanol: 16 mg/mL (56.28 mM); Water: Insoluble
• 특정 회전[α]: -84 ° (C=2, EtOH)
• 녹는점(°C): 166℃

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 10236-47-2, the molecular formula is C27H32O14, and the molecular weight is 580.53 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.