NHS-PEG-NHS - ≥95%, MW 1000 Da

Cat. No.: N164055

GRADE & PURITY ≥95%, MW 1000 Da

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

N-hydroxylsuccinimide (NHS) functionalized polyethylene glycol (PEG-NHS) is an amino (-NH₂) reactive PEG derivative that can be used to modify protein, peptide or any other surfaces with their available amino groups. NHS esters react with primary amine groups at pH 7~8.5 to form stable amide bonds.Compared to other PEG NHS ester derivatives, our succinimidyl carbonate (SC) functionalized mPEG-NHS offers superior reactivity and higher stability in aqueous solution. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. Primary amines react with NHS esters by nucleophilic attack and NHS is released as a byproduct. Hydrolysis of the NHS-ester competes with the reaction in aqueous solution and increases with increasing pH.

Specifications

사양 및 순도

≥95%, MW 1000 Da

생화학 및 생리적 메커니즘

Generally, a 10 to 50-fold molar excess of NHS PEG over the amount of amine-containing material results in sufficient conjugation.

Materials Required:

• Conjugation buffer: Sodium bicarbonate 100 mM buffer, pH 8.5 or other amine-f

보관 조건

Protected from light,Store at -20°C,Argon charged

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥95%

화학 및 물리적 특성

• 용해성: Off-white/white solid or viscous liquid depends on molecule weight;Soluble in regular aqeous solution as well as most organic solvents
• 감도: Moisture & light sensitive

참고 문헌

1. Qunfei Zhang, Xiang Liu, Hongqiang Liu, Shufen Li, Zhenping An, Zujian Feng.  (2024)  Construction of bupivacaine-loaded gelatin-based hydrogel delivery system for sciatic nerve block in mice.  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,      [PMID:38804067] [10.1002/jbm.a.37754]