Nigericin - Moligand™, 10 mM in Ethanol , CAS No.28380-24-7

CAS: 28380-24-7 Cat. No.: N1495817 분자식: C₄₀H₆₈O₁₁ 분자량: 724.96 Beilstein Registry Number: 3892398 EC 번호: 686-881-8 PubChem CID: 34230

GRADE & PURITY Moligand™, 10 mM in Ethanol

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC.

Specifications

사양 및 순도

Moligand™, 10 mM in Ethanol

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

이름과 식별자

• 이성체 SMILES: C[C@H]1CC[C@@H](O[C@H]1[C@@H](C)C(=O)O)C[C@@H]2C[C@H]([C@H]([C@@]3(O2)[C@@H](C[C@@](O3)(C)[C@H]4CC[C@@](O4)(C)[C@H]5[C@H](C[C@@H](O5)[C@@H]6[C@H](C[C@H]([C@@](O6)(CO)O)C)C)C)C)C)OC
• PubChem CID: 34230
• 분자량: 724.96
• Beilstein: 3892398

참고 문헌

1. Junyong Sun, Pinghua Ling, Feng Gao.  (2017)  A Mitochondria-Targeted Ratiometric Biosensor for pH Monitoring and Imaging in Living Cells with Congo-Red-Functionalized Dual-Emission Semiconducting Polymer Dots.  ANALYTICAL CHEMISTRY,      [PMID:29039196] [10.1021/acs.analchem.7b03154]

2. Tingwang Guo, Gang Chen, Lin Yang, Jia Deng, Yun Pan.  (2024)  Piezo1 inhibitor isoquercitrin rescues neural impairment mediated by NLRP3 after intracerebral hemorrhage.  EXPERIMENTAL NEUROLOGY,      [PMID:38857751] [10.1016/j.expneurol.2024.114852]

자주 묻는 질문

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 28380-24-7, the molecular formula is C40H68O11, and the molecular weight is 724.96 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.