NRD167 , CAS No.2166487-23-4

CAS: 2166487-23-4 Cat. No.: N419999

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Sequence:Z-Lys(thiourea-beta-Ala-OEt)-Trp-Isopropylamine

Specifications

동의어

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

생화학 및 생리적 메커니즘

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SI

보관 조건

Protected from light,Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

화학 및 물리적 특성

• 용해성: DMSO: 2 mg/mL, clear
• 감도: Light sensitive

참고 문헌

1. Zekun Liu, Jie Hu, Yinan Lin, Chuang Ge, Yuru Shao, Mengmeng Bao, Mengjie Liu, Shilin Jia, Yating Li, Xiaozhi Xu, Ruiyan Li, Qizhou Jiang, Fangrong Yan, Fei Xiao, Junmei Ye.  (2025)  SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.  LIVER INTERNATIONAL,  45  (12): (e70433).  [PMID:41221659] [10.1111/liv.70433]