OARV-771 - ≥98% , CAS No.2683008-37-7

CAS: 2683008-37-7 Cat. No.: O651646 분자식: C₄₉H₅₉ClN₈O₈S₂ 분자량: 987.62

등급 & 순도 ≥98%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Application

PROTAC

개요

OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC 50 s of 6, 1, and 4 nM for Brd4 , Brd2 and Brd3 , respectively

In Vitro

OARV-771 shows antiproliferative effect with an EC 50 value of 4 nM in MV4;11. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:BRD4 6 nM (DC 50 ) BRD2 1 nM (DC 50 ) BRD3 4 nM (DC 50 ) VHL

사양

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC 50 s of 6, 1, and 4 nM for Brd4 , Brd2 and Brd3 , respectively.

보관 조건

Store at -20°C,Desiccated

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥98%

이름과 식별자

분자량

987.62

화학 및 물리적 특성

• 용해성: DMSO : 100 mg/mL (101.25 mM; Need ultrasonic)