ODN D-SL03 - ≥99% , CAS No.1198621-85-0

CAS: 1198621-85-0 Cat. No.: O649166 분자량: 9345.00

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

개요

ODN D-SL03 is a C class CpG oligonucleotides , can induce stimulate PBMCs to produce high level of IFN-α . ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'

In Vitro

ODN D-SL03 (0-3 μg/mL; 36 h) significantly induces IFN-α production in PBMCs at 0.19 μg/mL. ODN D-SL03 (3 μg/mL; 18 or 36 h) activates immune cells including B, NK, T and monocyte cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN D-SL03 (25 μg per mouse; Peritumoral injection) induces significant inhibition of tumor growth . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c mice (6-8 weeks; inoculated with 5×10 5 EMT6 cells) Dosage: 25 μg per mouse Administration: Peritumoral injection, six times in one-day interval, for 0-100 days Result: Induced significant inhibition of tumor growth.

Form:Solid

IC50& Target:IFN-α

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

ODN D-SL03 is a C class CpG oligonucleotides , can induce stimulate PBMCs to produce high level of IFN-α . ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets

보관 조건

Store at -20°C,Desiccated

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥99%

이름과 식별자

• 정식 스마일: [DNA, d(P-thio)(T-C-G-C-G-A-A-C-G-T-T-C-G-C-C-G-C-G-T-T-C-G-A-A-C-G-C-G-G)]
• 분자량: 9345.00

화학 및 물리적 특성

• 용해성: H2O : ≥ 20 mg/mL (2.14 mM)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1198621-85-0, and the molecular weight is 9345.00 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.