OSMI-4 - 10mM in DMSO , CAS No.2260791-14-6

CAS: 2260791-14-6 Cat. No.: O422714 분자식: C₂₇H₂₆ClN₃O₇S₂ 분자량: 604.09 PubChem CID: 137319721

등급 & 순도 10mM in DMSO

Synonyms

ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells.

Targets

OGT (Cell-free assay) 3 μM(EC50)

In vitro

OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology.

Cell Research(from reference)

Cell lines：HEK293T cells 

Concentrations：5 μM, 10 μM, 20 μM 

Incubation Time：2 h, 8 h, 16 h, 24 h 

사양

동의어

ethyl (R)-N-(2-((7-chloro-2-oxo-1,2-dihydroquinoline)-6-sulfonamido)-2-(2-methoxyphenyl)acetyl)-N-(thiophen-2-ylmethyl)glycinate

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

제품 특성

ALogP

3.175

HBD 수

2

회전 가능한 결합

12

이름과 식별자

Pubchem Sid

528766484

정식 스마일

CCOC(=O)CN(CC1=CC=CS1)C(=O)C(C2=CC=CC=C2OC)NS(=O)(=O)C3=C(C=C4C(=C3)C=CC(=O)N4)Cl

IUPAC Name

ethyl 2-[[(2R)-2-[(7-chloro-2-oxo-1H-quinolin-6-yl)sulfonylamino]-2-(2-methoxyphenyl)acetyl]-(thiophen-2-ylmethyl)amino]acetate

InChIKey

STPSLAZMEWZDAJ-AREMUKBSSA-N

INCHI

1S/C27H26ClN3O7S2/c1-3-38-25(33)16-31(15-18-7-6-12-39-18)27(34)26(19-8-4-5-9-22(19)37-2)30-40(35,36)23-13-17-10-11-24(32)29-21(17)14-20(23)28/h4-14,26,30H,3,15-16H2,1-2H3,(H,29,32)/t26-/m1/s1

PubChem CID

137319721

분자량

604.09

화학 및 물리적 특성

• DMSO(mg/mL) 최대 용해도: 100
• DMSO(mM) 최대 용해도: 165.538247612111
• 물(mg/mL) 최대 용해도: ＜1