≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
OSS_128167 (SIRT6-IN-1) is a specificSIRT6inhibitor withIC50values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Targets
SIRT6 (Cell-free); SIRT2 (Cell-free); SIRT1 (Cell-free) 89 μM; 751 μM; 1578 μM
In vitro
OSS-128167 is a selective compounds toward SIRT6 with IC50 values toward SIRT1 and SIRT2 being approximately 20 times higher. It is cell permeable and active in cultured cells. OSS-128167 increases H3K9 acetylation and GLUT-1 expression.
Cell Research(from reference)
Cell lines：BxPC3 cells
Concentrations：100 μM
Incubation Time：0, 2, 6, 18, 24 h
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| 분류 | Benzene and substituted derivatives |
| Subclass | Anilides |
| Intermediate Tree Nodes | Aromatic anilides |
| Direct Parent | Benzanilides |
| Alternative Parents | 2-furanilides Salicylic acids Benzamides Benzoic acids 2-heteroaryl carboxamides Furoic acid and derivatives Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids Vinylogous acids Heteroaromatic compounds Secondary carboxylic acid amides Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organooxygen compounds Organopnictogen compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Benzanilide - 2-furanilide - Furanilide - Salicylic acid or derivatives - Salicylic acid - Hydroxybenzoic acid - Benzoic acid or derivatives - Benzoic acid - Benzamide - Benzoyl - 2-heteroaryl carboxamide - Furoic acid or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Furan - Heteroaromatic compound - Vinylogous acid - Carboxamide group - Secondary carboxylic acid amide - Monocarboxylic acid or derivatives - Oxacycle - Carboxylic acid - Carboxylic acid derivative - Organoheterocyclic compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound |
| 설명 | This compound belongs to the class of organic compounds known as benzanilides. These are aromatic compounds containing an anilide group in which the carboxamide group is substituted with a benzene ring. They have the general structure RNC(=O)R', where R,R'= benzene. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | 날짜 | 항목 |
|---|---|---|---|
 F2214789 | Certificate of Analysis | Mar 04, 2025 | O414086 |
| F2214790 | Certificate of Analysis | Mar 04, 2025 | O414086 |
| J2431155 | Certificate of Analysis | May 26, 2022 | O414086 |
| L2404267 | Certificate of Analysis | May 26, 2022 | O414086 |
| 용해성 | Solubility (25°C) In vitro DMSO: 73 mg/mL (199.27 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| 분자량 | 366.300 g/mol |
| XLogP3 | 2.700 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 5 |
| Exact Mass | 366.085 Da |
| Monoisotopic Mass | 366.085 Da |
| Topological Polar Surface Area | 129.000 Ų |
| Heavy Atom Count | 27 |
| Formal Charge | 0 |
| Complexity | 568.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
