Name: PD 180970 - ≥98%(HPLC) , CAS No.287204-45-9
SKU: P287860
Availability: InStock

PD 180970 - ≥98%(HPLC) , CAS No.287204-45-9

CAS: 287204-45-9 Cat. No.: P287860 분자식: C₂₁H₁₅Cl₂FN₄O 분자량: 429.27 EC 번호: 683-687-5 PubChem CID: 5311104

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PD 180970 - ≥98%(HPLC) CAS No(287204-45-9) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥98%(HPLC)

Synonyms

UNII-TSO2IAD7WJ | BDBM166759 | FT-0765936 | PD 180970 | SCHEMBL256711 | Linrodostat(BMS-986205) | PD180970 | PD-180970 | (2S)-2-((2R,3S,4R,5R)-(5-(4-Aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy)phenoxy-(S)-pho

Storage

20°C에서 보관

Shipped In

아이스 박스 + 아이스 패드

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

20°C에서 보관 Ships 아이스 박스 + 아이스 패드 Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

제품 설명: PD180970

PD180970은 p210Bcr-Abl의 자가 인산화를 억제하는 IC50이 5 nM인 매우 강력하고 ATP와 경쟁하는 p210Bcr-Abl 키나아제 억제제입니다. PD180970은 또한 각각 0.8nm와 50nm의 IC50으로 Src 및 KIT 키나아제를 억제합니다. PD180970은 K562 백혈병 세포의 세포 사멸을 유도하며 만성 골수성 백혈병 연구에 사용될 수 있습니다.

Specifications

동의어

사양 및 순도

≥98%(HPLC)

생화학 및 생리적 메커니즘

만성 골수성 백혈병(CML) K562 세포에서 선택적으로 세포 사멸을 유도하는 p210bcr/abltyrosine 키나아제의 ATP 경쟁 억제제. Gab2, CrkL 및 p210bcr/abl의 비보티로신 인산화를 억제합니다(IC50값은 각각 80, 80 및 170 nM입니다). Pote

보관 조건

20°C에서 보관

배송

아이스 박스 + 아이스 패드

작업 유형

INHIBITOR

순수함

≥98%(HPLC)

이름과 식별자

Pubchem Sid	528766543
정식 스마일	CC1=C(C=CC(=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl)F
IUPAC Name	6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one
InChIKey	SLCFEJAMCRLYRG-UHFFFAOYSA-N
INCHI	1S/C21H15Cl2FN4O/c1-11-8-13(6-7-17(11)24)26-21-25-10-12-9-14(20(29)28(2)19(12)27-21)18-15(22)4-3-5-16(18)23/h3-10H,1-2H3,(H,25,26,27)
이성체 SMILES	CC1=C(C=CC(=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl)F
PubChem CID	5311104
분자량	429.27

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 분류 Pyridines and derivatives
    - Subclass Phenylpyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
분류	Pyridines and derivatives
Subclass	Phenylpyridines
Intermediate Tree Nodes	Not available
Direct Parent	Phenylpyridines
Alternative Parents	Pyrido[2,3-d]pyrimidines Aniline and substituted anilines Dichlorobenzenes Toluenes Pyridinones Aminopyrimidines and derivatives Fluorobenzenes Aryl chlorides Aryl fluorides Heteroaromatic compounds Lactams Azacyclic compounds Hydrocarbon derivatives Organic oxides Organochlorides Organofluorides Organooxygen compounds Amines
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	3-phenylpyridine - Pyrido[2,3-d]pyrimidine - Pyridopyrimidine - 1,3-dichlorobenzene - Aniline or substituted anilines - Aminopyrimidine - Chlorobenzene - Fluorobenzene - Halobenzene - Pyridinone - Toluene - Aryl chloride - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Pyrimidine - Heteroaromatic compound - Lactam - Azacycle - Organochloride - Organohalogen compound - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Amine - Organofluoride - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as phenylpyridines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond.
External Descriptors	organofluorine compound - dichlorobenzene - pyridopyrimidine
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

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리뷰

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Lot Number	Certificate Type	날짜	항목
D2317057	Certificate of Analysis	Mar 10, 2023	P287860
D2317074	Certificate of Analysis	Mar 10, 2023	P287860
D2317170	Certificate of Analysis	Mar 10, 2023	P287860
D2317182	Certificate of Analysis	Mar 10, 2023	P287860
D2317188	Certificate of Analysis	Mar 10, 2023	P287860
I2525077	Certificate of Analysis	Mar 10, 2023	P287860

용해성	Solvent:DMSO, Max Conc. mg/mL: 21.46, Max Conc. mM: 50
분자량	429.300 g/mol
XLogP3	5.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	428.061 Da
Monoisotopic Mass	428.061 Da
Topological Polar Surface Area	58.100 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	640.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1