PD128907 HCl - ≥98% , CAS No.112960-16-4

CAS: 112960-16-4 Cat. No.: P129442 분자식: C₁₄H₁₉NO₃·HCl 분자량: 285.77

GRADE & PURITY ≥98%

Synonyms

trans-(+/-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride | (+/-)-PD 128,907 hydrochloride, solid, >=98% (HPLC) | 2,3-Dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone | EU-0100988 | PD128907Hydrochloride | R(

Storage

20°C에서 보관

Shipped In

아이스 박스 + 아이스 패드

개요

PD 128907 HCl은 강력하고 선택적인 도파민 D3 수용체 작용제로, EC50이 0.64 nM이며 도파민 D2 수용체에 비해 53배의 선택성을 나타냅니다.

Specifications

동의어

trans-(+/-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-aza-phenanthren-6-ol hydrochloride | (+/-)-PD 128,907 hydrochloride, solid, >=98% (HPLC) | 2,3-Dimethoxy-5-methyl-6-(farnesylfarnesyl)-1,4-benzoquinone | EU-0100988 | PD128907Hydrochloride | R(

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

선택적 D3 도파민 수용체 작용제.강력한 선택적 D 3 수용체 작용제(K i = 2.3 nM). 도파민 방출을 억제합니다. 급성 해리된 NAc 뉴런에서 GABAAR 전류를 감소시킵니다. 생체 내에서 운동 억제 효과를 나타냅니다.

보관 조건

20°C에서 보관

배송

아이스 박스 + 아이스 패드

참고

가능하면 당일에 용액을 준비하여 사용하는 것이 좋습니다. 그러나 미리 원액을 만들어야 하는 경우에는 -20°C에서 단단히 밀봉된 바이알에 소량씩 보관하는 것이 좋습니다. 일반적으로 최대 한 달 동안 사용할 수 있습니다. 사용하기 전에 바이알을 개봉하기 전에 제품을 실온에서 1시간 이상 평형화할 것을 권장합니다. 용해도, 사용법 및 취급에 대한 추가 정보가 필요하신가요? 자주 묻는 질문(FAQ) 페이지에서 자세한 내용을 확인하세요.

순수함

≥98%

이름과 식별자

• Pubchem Sid: 528766556
• 정식 스마일: CCCN1CCOC2C1COC3=C2C=C(C=C3)O.Cl
• IUPAC Name: (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol;hydrochloride
• InChIKey: DCFXOTRONMKUJB-QMDUSEKHSA-N
• INCHI: 1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
• 이성체 SMILES: CCCN1CCO[C@H]2[C@H]1COC3=C2C=C(C=C3)O.Cl
• WGK 독일: 3
• 분자량: 285.77
• Reaxy-Rn: 37356230
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37356230&ln=

관련 대상(인간)

HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

Discover Target: HTR2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERG Tbio Transcriptional regulator ERG (5589 Activities)

Discover Target: ERG

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LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

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BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

Discover Target: MPHOSPH8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)

Discover Target: GLS

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관련 대상(비인간)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Npsr1 Neuropeptide S receptor (260 Activities)

Discover Target: Npsr1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

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작용 메커니즘

화학 및 물리적 특성

• 용해성: DMSO 12 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• 분자량: 285.760 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 285.113 Da
• Monoisotopic Mass: 285.113 Da
• Topological Polar Surface Area: 41.900 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 286.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3