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PD153035 HCl - ≥98%(HPLC) , CAS No.183322-45-4

CAS: 183322-45-4 Cat. No.: P129384 분자식: C16H14BrN3O2·HCl 분자량: 396.67 EC 번호: 803-231-2
COA
PD153035 HCl - ≥98%(HPLC) CAS No(183322-45-4) by Aladdin Scientific
주문 가능
등급 & 순도 ≥98%(HPLC)
Synonyms
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-aminium chloride|ZM252868|PD153035 HCl (SU-5271, AG1517)|PD153035 (Hydrochloride);SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride)|ZM 252868 HCl|4,6,6-Trimethyl-2-mercapto-3,6-dihydropyrimidine|4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochloride (1:1)|PD153035 (Hydrochloride)|SU 5271|(4-BROMO-2-FORMYLPHENOXY)ACETICACID|N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine Hydrochloride|AG 1517 hydrochloride|PD153035.HCl|PD-153035.HCl|6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride|WHI-P-79 HYDROCHLORIDE|ZM 252868|PD153035 HCl|PD-153035 HCl|AG 1517|PD 153035 HYDROCHLORIDE|Diferaloylmethane|Tyrphostin AG 1517|4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-, MONOHYDROCHLORIDE|AG-1517 HYDROCHLORIDE|N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride|N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-aminehydrochloride|PD153035 hydrochloride|PD-153035 hydrochloride|PD 153035.HCl|6,7-DIMETHOXY-4-(N-(3-BROMOPHENYL)AMINO)QUINAZOLINE HYDROCHLORIDE|4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE|N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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USA
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10mg
P129384-10mg
3 재고 있음
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US$61.90
50mg
P129384-50mg
3 재고 있음
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US$125.90
250mg
P129384-250mg
2 재고 있음
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US$410.90
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Safety data
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데이터시트
SP
사양서
개요 사양 이름과 식별자 고급 데이터 Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 자주 묻는 질문과 기사 솔루션 계산기 리뷰

개요

PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src.
A potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase

사양

동의어
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-aminium chloride | ZM252868 | PD153035 HCl (SU-5271, AG1517) | PD153035 (Hydrochloride);SU-5271 (Hydrochloride); AG1517 (Hydrochloride); ZM 252868 (Hydrochloride) | ZM 252868 HCl | 4,6,6-Trimethyl-2-mercapto-3,6-dihydropyrimidine | 4-Quinazolinamine, N-(3-bromophenyl)-6,7-dimethoxy-, hydrochlori Show more
사양 및 순도
≥98%(HPLC)
생화학 및 생리적 메커니즘
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
작업 유형
INHIBITOR
순수함
≥98%(HPLC)
이름과 식별자
Pubchem Sid
528766557
정식 스마일
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
IUPAC Name
N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine;hydrochloride
InChIKey
ZJOKWAWPAPMNIM-UHFFFAOYSA-N
INCHI
1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H
이성체 SMILES
COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
WGK 독일
3
분자량
396.67
Reaxy-Rn
7400679
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7400679&ln=

고급 데이터

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganoheterocyclic compounds
분류Diazanaphthalenes
SubclassBenzodiazines
Intermediate Tree Nodes Quinazolines
Direct ParentQuinazolinamines
Alternative Parents Anisoles  Aniline and substituted anilines  Bromobenzenes  Aminopyrimidines and derivatives  Alkyl aryl ethers  Imidolactams  Aryl bromides  Heteroaromatic compounds  Secondary amines  Azacyclic compounds  Organopnictogen compounds  Organobromides  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents Quinazolinamine - Anisole - Aniline or substituted anilines - Alkyl aryl ether - Aminopyrimidine - Bromobenzene - Halobenzene - Aryl bromide - Aryl halide - Monocyclic benzene moiety - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Ether - Azacycle - Secondary amine - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Hydrocarbon derivative - Organic oxygen compound - Amine - Organopnictogen compound - Organic nitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
설명This compound belongs to the class of organic compounds known as quinazolinamines. These are heterocyclic aromatic compounds containing a quianazoline moiety substituted by one or more amine groups.
External Descriptors Not available
3D 구조
상호 작용 화학 구조 모델





관련 대상(인간)
EGFR Tclin Epidermal growth factor receptor (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERBB4 Tclin Receptor protein-tyrosine kinase erbB-4 (2748 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
관련 대상(비인간)
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
작용 메커니즘
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate Type날짜항목
F1510078F1510078Certificate of AnalysisFeb 08, 2025 P129384
화학 및 물리적 특성
용해성Solvent:DMSO, Max Conc. mg/mL: 3.97, Max Conc. mM: 10 with gentle warming
감도Heat Sensitive
녹는점(°C)265 °C
분자량396.700 g/mol
XLogP3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass395.004 Da
Monoisotopic Mass395.004 Da
Topological Polar Surface Area56.300 Ų
Heavy Atom Count23
Formal Charge0
Complexity360.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
자주 묻는 질문과 기사
Quinazoline (Quinazoline, 1,3-Diazanaphthalene) Research Selection Guide: Structural Features, Application Scenarios, and Key Reagent Navigation (Tables 1–4)
Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides
Tags:
Nitrogen-containing heterocycles Quinazoline
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