PDE4B-IN-3 - ≥99% , CAS No.P659387

CAS: P659387 Cat. No.: P659387 분자식: C₃₀H₃₅N₃O₄S₂ 분자량: 565.75

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities.

Appearance:Solid

IC50& Target:PDE4B 0.94 μM (IC 50 )

In Vitro:PDE4B-IN-3 (compound f4) has good inhibitory activity on the production of NO, TNF-α and IL-1β with IC 50 values of 20.40 μM, 23.48 μM, and 18.98 μM in RAW264.7 cells. PDE4B-IN-3 could also inhibit the expression of iNOS and COX-2 in RAW264.7 cells.

In Vivo:In vivo studies shows that PDE4B-IN-3 (compound f4; 10-30mg/kg) could improve the degree of foot swelling and knee joint pathology in adjuvant-induced arthritic rats and decrease the levels of serum inflammatory factors TNF-α and IL-1β in a dose-dependen

Biological Activity:PDE4B-IN-3 is a potent PDE4B inhibitor with an IC 50 of 0.94 μM. PDE4B-IN-3 has anti-inflammatory activities.

Specifications

사양 및 순도

≥99%

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

분자량

565.75

화학 및 물리적 특성

• 용해성: DMSO : 50 mg/mL (88.38 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.