PF-06263276 - ≥99% , CAS No.1421502-62-6

Name: PF-06263276 - ≥99% , CAS No.1421502-62-6
SKU: P646949
Availability: InStock

CAS: 1421502-62-6 Cat. No.: P646949 분자식: C₃₁H₃₁FN₈O₂ 분자량: 566.63 PubChem CID: 135567296

COA

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PF-06263276 - ≥99% CAS No(1421502-62-6) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥99%

Synonyms

SCHEMBL20767494 | PF-06263276 | 7GS | {2-[6-(2-Ethyl-5-Fluoro-4-Hydroxyphenyl)-2h-Indazol-3-Yl]-3,4,6,7-Tetrahydro-5h-Imidazo[4,5-C]pyridin-5-Yl}[5-(Piperidin-1-Yl)pyrazin-2-Yl]methanone | SCHEMBL14658676 | (2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-inda

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 솔루션 계산기 리뷰 자주 묻는 질문

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC 50 s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1 , JAK2 , JAK3 and TYK2 , respectively

Form:Solid

IC50& Target:JAK1 2.2 nM (IC 50 ) JAK2 23.1 nM (IC 50 ) JAK3 59.9 nM (IC 50 ) Tyk2 29.7 nM (IC 50 )

Specifications

동의어

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC 50 s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1 , JAK2 , JAK3 and TYK2 , respectively.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

작업 유형

INHIBITOR

순수함

≥99%

이름과 식별자

정식 스마일	CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C(=O)C6=CN=C(C=N6)N7CCCCC7)F)O
IUPAC Name	[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone
InChIKey	XDJGNPSZQSWJCV-UHFFFAOYSA-N
INCHI	1S/C31H31FN8O2/c1-2-18-13-27(41)22(32)14-21(18)19-6-7-20-24(12-19)37-38-29(20)30-35-23-8-11-40(17-26(23)36-30)31(42)25-15-34-28(16-33-25)39-9-4-3-5-10-39/h6-7,12-16,41H,2-5,8-11,17H2,1H3,(H,35,36)(H,37,38)
이성체 SMILES	CCC1=CC(=C(C=C1C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)CN(CC5)C(=O)C6=CN=C(C=N6)N7CCCCC7)F)O
PubChem CID	135567296
분자량	566.63

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - 분류 Imidazopyridines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
분류	Imidazopyridines
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Imidazopyridines
Alternative Parents	Pyrazinecarboxamides Imidazopiperidines Indazoles 2-heteroaryl carboxamides Dialkylarylamines O-fluorophenols 1-hydroxy-2-unsubstituted benzenoids Aminopyrazines Fluorobenzenes Piperidines Aryl fluorides Imidolactams Imidazoles Heteroaromatic compounds Pyrazoles Tertiary carboxylic acid amides Azacyclic compounds Hydrocarbon derivatives Organooxygen compounds Organopnictogen compounds Organofluorides Organic oxides
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzopyrazole - Imidazopiperidine - Imidazopyridine - Indazole - Pyrazine carboxylic acid or derivatives - Pyrazinecarboxamide - 2-heteroaryl carboxamide - 2-halophenol - 2-fluorophenol - Dialkylarylamine - Aminopyrazine - Fluorobenzene - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Piperidine - Imidolactam - Benzenoid - Pyrazine - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Heteroaromatic compound - Azole - Tertiary carboxylic acid amide - Pyrazole - Imidazole - Carboxamide group - Azacycle - Carboxylic acid derivative - Organooxygen compound - Organic oxygen compound - Organopnictogen compound - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as imidazopyridines. These are organic polycyclic compounds containing an imidazole ring fused to a pyridine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

분자량	566.600 g/mol
XLogP3	4.100
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	566.255 Da
Monoisotopic Mass	566.255 Da
Topological Polar Surface Area	127.000 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	941.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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리뷰

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1421502-62-6, the molecular formula is C31H31FN8O2, and the molecular weight is 566.63 g/mol. InChIKey XDJGNPSZQSWJCV-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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