PF-06471553 - 10mM in DMSO , CAS No.1808094-07-6

CAS: 1808094-07-6 Cat. No.: P656363 분자식: C₂₃H₂₅N₅O₄S 분자량: 467.54 PubChem CID: 122189255

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM.

In Vitro

PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC 50 , >50 μM), DGAT2 (IC 50 , >100 μM), MGAT1 (IC 50 , 14.9 μM), and MGAT2 (IC 50 , 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC 50 of 205 nM (pIC 50 , 6.69). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 92 nM (MGAT3)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC 50 of 92 nM.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

INHIBITOR

이름과 식별자

• 이성체 SMILES: COC1=CC=CC(=C1)CC(=O)N2CC3=C(C2)C=C(C=C3)S(=O)(=O)NC4=NN(N=C4)C5CCC5
• PubChem CID: 122189255
• MeSH 용어: N-(2-cyclobutyl-2H-1,2,3-triazol-4-yl)-2-(2-(3-methoxyphenyl)acetyl)isoindoline-5-sulfonamide;PF-06471553
• 분자량: 467.54

관련 대상(인간)

MGAT3 Tchem Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (4 Activities)

Discover Target: MGAT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.