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PF-06648671 - ≥98% , CAS No.1587727-31-8
주문 가능
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
개요
PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM) . PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease
In Vitro
In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: γ-secretase
Specifications
사양 및 순도
≥98%
생화학 및 생리적 메커니즘
PF-06648671xa0is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM) . PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease.
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
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작업 유형
MODULATOR
순수함
≥98%
이름과 식별자
| 정식 스마일 | CC1=CN(C=N1)C2=CC=C3C(=O)N(CCN3C2=O)C(C)C4CCC(O4)C5=CC(=C(C=C5C(F)(F)F)Cl)F |
|---|---|
| IUPAC Name | 2-[1-[5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]oxolan-2-yl]ethyl]-7-(4-methylimidazol-1-yl)-3,4-dihydropyrido[1,2-a]pyrazine-1,6-dione |
| InChIKey | AKCDDYGYIGPEKL-UHFFFAOYSA-N |
| INCHI | 1S/C25H23ClF4N4O3/c1-13-11-32(12-31-13)19-3-4-20-24(36)33(7-8-34(20)23(19)35)14(2)21-5-6-22(37-21)15-9-18(27)17(26)10-16(15)25(28,29)30/h3-4,9-12,14,21-22H,5-8H2,1-2H3 |
| PubChem CID | 134818837 |
| 분자량 | 538.92 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
3D 구조
상호 작용 화학 구조 모델
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
솔루션 계산기
리뷰
고객 리뷰
자주 묻는 질문
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 1587727-31-8, the molecular formula is C25H23ClF4N4O3, and the molecular weight is 538.92 g/mol. InChIKey AKCDDYGYIGPEKL-UHFFFAOYSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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