PF 915275 - ≥98%(HPLC) , CAS No.857290-04-1

CAS: 857290-04-1 Cat. No.: P288201 분자식: C18H14N4O2S 분자량: 350.39 PubChem CID: 23725123
주문 가능
GRADE & PURITY ≥98%(HPLC)
Synonyms
PF-915275; PF915275 | PF-915275 | SCHEMBL4384483 | BDBM29864 | N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide | BCP28049 | 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide | EC-000.2428 | N-(Pyridin-2-yl) arylsulfonamide, 26
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
★
Size
USA
독일 (EU)*
Price
Qty
5mg
P288201-5mg
1 재고 있음
—

US$113.90

US$170.90
저장 US$57.00 (33.35%)
10mg
P288201-10mg
1 재고 있음
—

US$204.90

US$307.90
저장 US$103.00 (33.45%)
25mg
P288201-25mg
3 재고 있음
—

US$447.90

US$671.90
저장 US$224.00 (33.34%)
50mg
P288201-50mg
2 재고 있음
—

US$758.90

US$1,138.90
저장 US$380.00 (33.37%)
100mg
P288201-100mg
1 재고 있음
—

US$1,286.90

US$1,930.90
저장 US$644.00 (33.35%)
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

동의어
PF-915275; PF915275 | PF-915275 | SCHEMBL4384483 | BDBM29864 | N-(6-Amino-2-pyridinyl)-4'-cyano-[1,1'-biphenyl]-4-sulfonamide | BCP28049 | 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide | EC-000.2428 | N-(Pyridin-2-yl) arylsulfonamide, 26
사양 및 순도
≥98%(HPLC)
생화학 및 생리적 메커니즘
Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki= 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytesin vitro(EC50= 15 n
보관 조건
Store at -20°C
배송
Ice chest + Ice pads
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작업 유형
INHIBITOR
순수함
≥98%(HPLC)
이름과 식별자
Pubchem Sid528766588
정식 스마일C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N
IUPAC NameN-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide
InChIKeyZESFDAKNYJQYKO-UHFFFAOYSA-N
INCHI1S/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22)
이성체 SMILES C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N
PubChem CID 23725123
분자량 350.39

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
분류Benzene and substituted derivatives
SubclassBiphenyls and derivatives
Intermediate Tree Nodes Not available
Direct ParentBiphenylcarbonitriles
Alternative Parents Benzenesulfonamides  Benzenesulfonyl compounds  Benzonitriles  Aminopyridines and derivatives  Organosulfonamides  Imidolactams  Heteroaromatic compounds  Aminosulfonyl compounds  Nitriles  Azacyclic compounds  Primary amines  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Biphenylcarbonitrile - Benzenesulfonamide - Benzenesulfonyl group - Benzonitrile - Aminopyridine - Pyridine - Imidolactam - Organosulfonic acid amide - Heteroaromatic compound - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Carbonitrile - Nitrile - Azacycle - Organoheterocyclic compound - Organosulfur compound - Organonitrogen compound - Organic nitrogen compound - Amine - Organic oxide - Cyanide - Primary amine - Hydrocarbon derivative - Organic oxygen compound - Aromatic heteromonocyclic compound
설명This compound belongs to the class of organic compounds known as biphenylcarbonitriles. These are organic compounds containing an acetonitrile with one hydrogen replaced by a biphenyl group.
External Descriptors Not available
3D 구조
상호 작용 화학 구조 모델





관련 대상(인간)
HSD11B1 Tclin Corticosteroid 11-beta-dehydrogenase isozyme 1 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSD17B2 Tchem Estradiol 17-beta-dehydrogenase 2 (1671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Liver microsomes (16955 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
관련 대상(비인간)
Hsd11b1 11-beta-hydroxysteroid dehydrogenase 1 (202 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hsd11b2 11-beta-hydroxysteroid dehydrogenase 2 (82 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD11B1 11-beta-hydroxysteroid dehydrogenase type 1 (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD11B1 Hydroxysteroid 11-beta dehydrogenase 1 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Slc5a7 High affinity choline transporter 1 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
작용 메커니즘
인증서(CoA, COO, BSE/TSE 및 분석 차트)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate Type날짜항목
G2229189Certificate of AnalysisJun 13, 2022 P288201
G2229190Certificate of AnalysisJun 13, 2022 P288201
G2229191Certificate of AnalysisJun 13, 2022 P288201
G2229192Certificate of AnalysisJun 13, 2022 P288201
G2229193Certificate of AnalysisJun 13, 2022 P288201
L2418205Certificate of AnalysisJun 13, 2022 P288201
L2420181Certificate of AnalysisJun 13, 2022 P288201
화학 및 물리적 특성
용해성Solvent:DMSO, Max Conc. mg/mL: 35.04, Max Conc. mM: 100
분자량350.400 g/mol
XLogP32.700
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass350.084 Da
Monoisotopic Mass350.084 Da
Topological Polar Surface Area117.000 Ų
Heavy Atom Count25
Formal Charge0
Complexity578.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
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