Pinacidil monohydrate - 10mM in DMSO , Sulfonylurea receptor 2, Kir6.2 opener, CAS No.85371-64-8, Sulfonylurea receptor 2, Kir6.2 opener

CAS: 85371-64-8 Cat. No.: P426344 분자식: C₁₃H₁₉N₅ · H₂O 분자량: 263.34 EC 번호: 622-053-4 PubChem CID: 55329

GRADE & PURITY 10mM in DMSO

Synonyms

PINACIDIL [JAN] | Z1617901125 | Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate | Tox21_110954 | 7B0ZZH8P2W | AFJCNBBHEVLGCZ-UHFFFAOYSA-N | (+/-)-N-Cyano-N'-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate | CCG-1011

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Pinacidil is a K+ channel opener. Pinacidil is demonstrated to induce relaxation of serotonin-produced contractions in porcine and human arterial rings. This action is suppressed by the ATP-dependent K+ (KATP) channel blockers Glibenclamide and Tetrapentylammonium salts, suggesting that relaxations induced by Pinacidil are mediated by opening of KATP channels.
A K+ channel activator; antihypertensive

Specifications

동의어

PINACIDIL [JAN] | Z1617901125 | Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate | Tox21_110954 | 7B0ZZH8P2W | AFJCNBBHEVLGCZ-UHFFFAOYSA-N | (+/-)-N-Cyano-N'-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydrate | CCG-1011

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

K + channel activator; hypotensor. Pinacidil is a KATP channel agonist. It can protect cardiomyocytes by preventing the loss of mitochondrial membrane potential. It can prevent the activation of caspase 3 in hypoxia / reoxygenation injury.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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작업 유형

OPENER

작동 메커니즘

Sulfonylurea receptor 2, Kir6.2 opener

이름과 식별자

• Pubchem Sid: 528770799
• 정식 스마일: CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O
• IUPAC Name: 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine;hydrate
• InChIKey: AFJCNBBHEVLGCZ-UHFFFAOYSA-N
• INCHI: 1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
• 이성체 SMILES: CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1.O
• WGK 독일: 3
• PubChem CID: 55329
• 분자량: 263.34

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Pyridines and derivatives
      • Subclass Hydropyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Pyridines and derivatives
• Subclass: Hydropyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Dihydropyridines
• Alternative Parents: Secondary ketimines Heteroaromatic compounds Propargyl-type 1,3-dipolar organic compounds Carboximidamides Azacyclic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Dihydropyridine - Heteroaromatic compound - Secondary ketimine - Azacycle - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Imine - Aromatic heteromonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as dihydropyridines. These are compounds containing a dihydropyridine moiety, which is a semi-saturated pyridine derivative with two double bonds.
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

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GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

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관련 대상(비인간)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 분자량: 263.340 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 263.175 Da
• Monoisotopic Mass: 263.175 Da
• Topological Polar Surface Area: 74.100 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 327.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3