Pomalidomide 4'-PEG3-acid - ≥95%(HPLC) , CAS No.2138440-82-9

CAS: 2138440-82-9 Cat. No.: P288042 분자식: C₂₂H₂₇N₃O₉ 분자량: 477.46 EC 번호: 195-070-3 PubChem CID: 132020335

등급 & 순도 ≥95%(HPLC)

Synonyms

Pomalidomide - linker 2 | 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid | Crosslinker−E3 Ligase ligand conjugate

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

개요

Product Application:

Protein degrader builiding block Pomalidomide-PEG3-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

사양

동의어

Pomalidomide - linker 2 | 3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid | Crosslinker−E3 Ligase ligand conjugate

사양 및 순도

≥95%(HPLC)

생화학 및 생리적 메커니즘

Functionalized cereblon ligand for PROTAC®research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PR

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥95%(HPLC)

이름과 식별자

Pubchem Sid

488202763

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488202763

정식 스마일

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCC(=O)O

IUPAC Name

3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid

InChIKey

QBYOEHKZQIFBGV-UHFFFAOYSA-N

INCHI

1S/C22H27N3O9/c26-17-5-4-16(20(29)24-17)25-21(30)14-2-1-3-15(19(14)22(25)31)23-7-9-33-11-13-34-12-10-32-8-6-18(27)28/h1-3,16,23H,4-13H2,(H,27,28)(H,24,26,29)

PubChem CID

132020335

분자량

477.46

화학 및 물리적 특성

• 분자량: 477.500 g/mol
• XLogP3: -0.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 14
• Exact Mass: 477.175 Da
• Monoisotopic Mass: 477.175 Da
• Topological Polar Surface Area: 161.000 Ų
• Heavy Atom Count: 34
• Formal Charge: 0
• Complexity: 775.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1