Pomalidomide-PEG₂-Alkyne - ≥95% , CAS No.P463546

CAS: P463546 Cat. No.: P463546 분자식: C₂₁H₂₁N₃O₇ 분자량: 427.41

GRADE & PURITY ≥95%

Synonyms

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(prop-2-yn-1-yloxy)ethoxy)propanamide | Crosslinker–E3 Ligase ligand conjugate | Template for synthesis of targeted protein degrader

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Description

Protein degrader builiding block Pomalidomide-PEG2-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

동의어

N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3-(2-(prop-2-yn-1-yloxy)ethoxy)propanamide | Crosslinker–E3 Ligase ligand conjugate | Template for synthesis of targeted protein degrader

사양 및 순도

≥95%

보관 조건

Protected from light,Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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순수함

≥95%

이름과 식별자

• 분자량: 427.41

화학 및 물리적 특성

• 감도: Moisture sensitive；Light sensitive