Prednisolone disodium phosphate - Moligand™, 10 mM in Water , CAS No.125-02-0

CAS: 125-02-0 Cat. No.: P1499394 분자식: C₂₁H₂₇Na₂O₈P 분자량: 484.39 EC 번호: 204-722-9 PubChem CID: 441409

GRADE & PURITY Moligand™, 10 mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others . Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced .

Specifications

사양 및 순도

Moligand™, 10 mM in Water

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

이름과 식별자

이성체 SMILES

C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=C[C@]34C)O.[Na+].[Na+]

RTECS

TU4153300

PubChem CID

441409

분자량

484.39

Reaxy-Rn

4795229

화학 및 물리적 특성

• 특정 회전[α]: 99° (C=1,pH 7.0 Buffer sol.)