Probucol - Moligand™, 10mM in DMSO , ATP-binding cassette sub-family A member 1 inhibitor, CAS No.23288-49-5, ATP-binding cassette sub-family A member 1 inhibitor

CAS: 23288-49-5 Cat. No.: P408795 분자식: C₃₁H₄₈O₂S₂ 분자량: 516.84 EC 번호: 245-560-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Information

Probucol Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

동의어

DH-581 | 4,​4'-​[(1-​methylethylidene)​bis(thio)​]​bis[2,​6-​bis(1,​1-​dimethylethyl)​-phenol

사양 및 순도

Moligand™, 10mM in DMSO

생화학 및 생리적 메커니즘

Probucol (DH-581) is an anti-hyperlipidemic drug by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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등급

Moligand™

작업 유형

INHIBITOR

작동 메커니즘

ATP-binding cassette sub-family A member 1 inhibitor

제품 특성

• ALogP: 11.3

이름과 식별자

• 이성체 SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
• RTECS: AL3705000
• 분자량: 516.84
• Reaxy-Rn: 2026253
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2026253&ln=

관련 대상(인간)

HPN Tchem Serine protease hepsin (1 Activities)

Discover Target: HPN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro
• 녹는점(°C): 128°C

참고 문헌

1. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang.  (2023)  Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy.  Acta Biomaterialia,      [PMID:38141933] [10.1016/j.actbio.2023.12.027]

2. Hongyan Lu, Guangzhao Yang, Fu Ran, Tianbin Gao, Changshan Sun, Qinfu Zhao, Siling Wang.  (2019)  Polymer-functionalized mesoporous carbon nanoparticles on overcoming multiple barriers and improving oral bioavailability of Probucol.  CARBOHYDRATE POLYMERS,      [PMID:31826471] [10.1016/j.carbpol.2019.115508]