≥99% 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
Protected from light,Store at -80°C Dry ice packs + Cold packs 출고. 정확한 사양은 로트별 COA를 확인하세요.
SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist ( EC 50 =135 nM). PW0787 suppresses psychostimulant behavior
In Vivo
PW0787 (0.3, 1, 3, or 10 mg/kg; IP) displays antipsychotic-like activity by significantly inhibiting amphetamine-induced hyperlocomotor behavior in mice . PW0787 is evaluated in rats after a single dose of 20 mg/kg by oral (PO) or 10 mg/kg by intravenous (IV) administration. PW0787 has excellent plasma exposure after PO (AUC 0-inf = 13,749 ng•h/mL) and IV dosing (AUC 0-inf =9030 ng•h/mL), as well as high maximum serum concentration following PO (C max =3407 ng/mL) and IV administration (C max =6726 ng/mL). Additionally, PW0787 displays good volume of plasma distribution (V ss =1.5 L/kg) and acceptable plasma clearance (CL=1.1 L/h/kg) after 10 mg/kg IV. Excellent oral bioavailability (F) with the value of 76% is observed . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Naïve male C57/BL6 mice weighing between 24 and 31 g Dosage: 0.3, 1, 3, or 10 mg/kg (dissolved in 0.9% saline containing 20% HP-β-CD with a final pH of the solution adjusted to 7.4) Administration: IP Result: Suppressed amphetamine (AMPH)-induced horizontal activity at both 3 mg/kg and 10 mg/kg doses.
Form:Solid
IC50& Target:EC50: 135 nM (GPR52)
위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
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| 용해성 | DMSO : 50 mg/mL (108.60 mM; Need ultrasonic) |
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