PX-478 2HCl - Moligand™, ≥98% , CAS No.685898-44-6

CAS: 685898-44-6 Cat. No.: P413792 분자식: C₁₃H₂₀Cl₄N₂O₃ 분자량: 394.12 PubChem CID: 11234794

GRADE & PURITY Moligand™, ≥98%

Synonyms

A867013 | PX 478 [WHO-DD] | Q27289565 | s7612 | CCG-268582 | PX 478 | AKOS030231369 | AS-76128 | DTXSID00218688 | SCHEMBL18548830 | AC2217 | BDBM50231387 | L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride | A14319 | PX478 | PX-478 | HY-

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Information

PX-478 2HCl PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.

Targets

HIF-1α

In vitro

PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.

In vivo

In HT-29 human colon cancer xenografts, PX-478 suppresses HIF-1alpha levels and inhibits the expression of HIF-1 target genes including vascular endothelial growth factor and the glucose transporter-1. In addition, PX-478 (100 or 120 mg/kg i.p.) also shows antitumor activity including cures against several established human tumor xenografts that is related to the levels of HIF-1α. In high-fat-diet mice, PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues.

Specifications

동의어

A867013 | PX 478 [WHO-DD] | Q27289565 | s7612 | CCG-268582 | PX 478 | AKOS030231369 | AS-76128 | DTXSID00218688 | SCHEMBL18548830 | AC2217 | BDBM50231387 | L-Phenylalanine, 4-(bis(2-chloroethyl)oxidoamino)-, dihydrochloride | A14319 | PX478 | PX-478 | HY-

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 2HCl induces apoptosis and has anti-tumor activity. Phase 1.

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

INHIBITOR

순수함

≥98%

제품 특성

• ALogP: -0.251
• HBD 수: 1
• 회전 가능한 결합: 8

이름과 식별자

• Pubchem Sid: 488197315
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488197315
• 정식 스마일: C1=CC(=CC=C1CC(C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
• IUPAC Name: 4-[(2S)-2-amino-2-carboxyethyl]-N,N-bis(2-chloroethyl)benzeneamine oxide;dihydrochloride
• InChIKey: GIGCDIVNDFQKRA-LTCKWSDVSA-N
• INCHI: 1S/C13H18Cl2N2O3.2ClH/c14-5-7-17(20,8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19;;/h1-4,12H,5-9,16H2,(H,18,19);2*1H/t12-;;/m0../s1
• 이성체 SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl
• PubChem CID: 11234794
• 분자량: 394.12

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • 분류 Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Phenylalanine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• 분류: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Phenylalanine and derivatives
• Alternative Parents: Phenylpropanoic acids Amphetamines and derivatives L-alpha-amino acids Nitrogen mustard compounds Aralkylamines Amino acids Trisubstituted amine oxides and derivatives Monocarboxylic acids and derivatives Carboxylic acids Hydrochlorides Hydrocarbon derivatives Monoalkylamines Carbonyl compounds Organic oxides Organic zwitterions Organochlorides Alkyl chlorides
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Phenylalanine or derivatives - 3-phenylpropanoic-acid - Alpha-amino acid - Amphetamine or derivatives - L-alpha-amino acid - Nitrogen mustard - Aralkylamine - Monocyclic benzene moiety - Benzenoid - Amino acid - N-oxide - Carboxylic acid - Monocarboxylic acid or derivatives - Trisubstituted n-oxide - Alkyl chloride - Primary amine - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organic zwitterion - Organic salt - Primary aliphatic amine - Hydrochloride - Carbonyl group - Hydrocarbon derivative - Organic oxide - Amine - Organic oxygen compound - Organic nitrogen compound - Alkyl halide - Aromatic homomonocyclic compound
• 설명: This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-468 (9477 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)

Discover Target: HIF1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

관련 대상(비인간)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro DMSO: 79 mg/mL (200.44 mM); Water: 79 mg/mL (200.44 mM); Ethanol: 20 mg/mL (50.74 mM)
• 감도: Moisture sensitive
• DMSO(mg/mL) 최대 용해도: 78
• DMSO(mM) 최대 용해도: 197.9092662
• 물(mg/mL) 최대 용해도: 78
• 물(mM) 최대 용해도: 197.9092662
• 분자량: 394.100 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 394.02 Da
• Monoisotopic Mass: 392.023 Da
• Topological Polar Surface Area: 81.400 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 304.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

자주 묻는 질문

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 685898-44-6, the molecular formula is C13H20Cl4N2O3, and the molecular weight is 394.12 g/mol. InChIKey GIGCDIVNDFQKRA-LTCKWSDVSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.