PXS-5120A - ≥98% , CAS No.2125955-70-4

CAS: 2125955-70-4 Cat. No.: P646363 분자식: C₂₂H₂₅ClFN₃O₄S 분자량: 481.97

등급 & 순도 ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

개요

PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 ( K i of 83 nM; pIC 50 of 8.4) over LOXL ( pIC 50 of 5.8)

In Vitro

PXS-5120A (Compound 12k) is a potent inhibitor of the LOXL2/3 enzyme and a moderate blocker of LOXL4. PXS-5120A inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, collagen oxidation assay, recombinant human LOXL3 and recombinant human LOXL4 with IC 50 s of 5 nM, 9 nM, 6 nM, 6 nM, 13 nM, 16 nM and 280 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PXS-5129A is readily absorbed following oral gavage, and once in the circulation, rapidly hydrolyzed to release PXS-5120 (free base) in vivo, affording plasma concentrations well above the LOXL2 IC 50 (6 nM) for a prolonged period (>6 h) in mice, while remaining well below the IC50 for LOX throughout . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:pKi: 8.4 (Lysyl Oxidase-like 2) and 5.8 (Lysyl Oxidase-like),Ki: 83 nM (Lysyl Oxidase-like 2)

사양

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 ( K i of 83 nM; pIC 50 of 8.4) over LOXL ( pIC 50 of 5.8).

보관 조건

Store at 2-8°C,Desiccated

배송

Wet ice

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순수함

≥98%

이름과 식별자

정식 스마일

O=C(C1=CC2=C(N(C/C(F)=C/CN)C(C)=C2C3=CC=CC(S(=O)(N(C)C)=O)=C3)C=C1)O.[H]Cl

분자량

481.97

화학 및 물리적 특성

• 용해성: DMSO : 125 mg/mL (259.35 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2125955-70-4, the molecular formula is C22H25ClFN3O4S, and the molecular weight is 481.97 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.