Rasarfin - 10mM in DMSO , CAS No.674359-73-0

CAS: 674359-73-0 Cat. No.: R656426 분자식: C₂₃H₂₄ClN₃O₃ 분자량: 425.91

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Rasarfin is a dual Ras and ARF6 inhibitor.

In Vitro

Rasarfin potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation. ?\nRasarfin blocks GPCR internalization through inhibition of ARF6. ?\nRasarfin treatment results in a dose-dependent reduction in MDA-MB-231 cells. ?\nRasarfin inhibits the recruitment of the clathrin adaptor AP-2 to β-arrestin2 and receptor internalization, both processes that require active ARF6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Rasarfin is a dual Ras and ARF6 inhibitor.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

이름과 식별자

• 분자량: 425.91