RC-3095 TFA - ≥98% , CAS No.1217463-61-0

CAS: 1217463-61-0 Cat. No.: R648024 분자식: C₅₈H₈₀F₃N₁₅O₁₁ 분자량: 1220.34

GRADE & PURITY ≥98%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

RC-3095 TFA is a selective bombesin / gastrin releasing peptide receptor ( GRPR ) antagonist RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

In Vivo

RC-3095 impairs aversive but not recognition memory in Wistar male rats . RC-3095 (0.3 mg/kg or 1 mg/kg; S.C.) shows anti-inflammatory effects in 2 experimental models of arthritis, collagen-induced arthritis (CIA) and antigen-induced arthritis (AIA). Arthritic mice treated with RC-3095 show a significant reduction in the concentrations of IL-17, IL-1 , and TNF, and showed a diminished expression of GRPR. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Balb/c wild-type mice (weighing 18-25 gm) with AIA model; Male DBA/1J inbred mice (weighing 18-25 gm) with CIA modelDosage: 1 mg/kg for AIA studies; 0.3 mg/kg or 1 mg/kg for CIA studies Administration: Injected SC twice a day for a total of 2 or 10 days for AIA studies; Administered SC twice a day for 10 days after the onset of the disease for CIA studies Result: Reduced neutrophil migration, mechanical hy pernociception, and proteoglycan loss in mice with AIA; Led to a significant reduction in arthritis clinical scores and the severity of disease in the CIA model.

Form:Solid

IC50& Target:Bombesin receptor,GRPR

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

RC-3095 TFA is a selective bombesin / gastrin releasing peptide receptor ( GRPR ) antagonist. RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice.

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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순수함

≥98%

이름과 식별자

• 분자량: 1220.34

화학 및 물리적 특성

• 용해성: H2O : 50 mg/mL (40.97 mM; Need ultrasonic)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1217463-61-0, the molecular formula is C58H80F3N15O11, and the molecular weight is 1220.34 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.