Recombinant Human EIF3I Protein

Cat. No.: rp192075

등급 & 순도 Carrier Free, His Tag, ≥90%(SDS-PAGE), See COA

Accession #

Q13347

Protein Tag

N-His

Expression system

E. coli

Endotoxin Concentration

<1.0 EU/μg

개요

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).
The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Post-translational: Phosphorylated by TGF-beta type II receptor.

사양

Product Name

Recombinant Human EIF3I Protein

동의어

eIF-3-beta | eIF3 beta | eIF3 p36 | eIF3-beta | eIF3-p36 | eIF3i | EIF3I_HUMAN | EIF3S2 | Eukaryotic translation initiation factor 3 subunit 2 | Eukaryotic translation initiation factor 3 subunit 2 beta | Eukaryotic translation initiation factor 3 subunit

등급

Carrier Free, His Tag

사양 및 순도

Carrier Free, His Tag, ≥90%(SDS-PAGE), See COA

내독소 농도

<1.0 EU/μg

아미노산

2-325 aa

시퀀스

MHHHHHHKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA​

가입 번호

Q13347

예상 분자량

37.3 kDa

SDS-PAGE

35.4 kDa, under reducing conditions.

분자 유형

Protein

Product Line

생물 제품

보관 및 배송

집중력

See COA

보관 조건

Store at -20°C,Avoid repeated freezing and thawing

배송

Ice chest + Ice pads

안정성 및 스토리지

Store at -20°C for 1 year. Avoid freeze/thaw cycle.

이미지

SDS-PAGE: Recombinant Human EIF3I Protein (rp192075)

Recombinant Human EIF3I Protein (rp192075) - SDS-PAGE
2 μg/lane of Recombinant Human EIF3I Protein was resolved with SDS-PAGE under reducing (R) condition and visualized by Coomassie® Blue staining, showing a band at 35.4 kDa.