RMC-0331 - ≥98% , CAS No.2488788-52-7

CAS: 2488788-52-7 Cat. No.: R648791 분자식: C₂₂H₂₅ClF₃N₅O₃ 분자량: 499.91 PubChem CID: 155687064

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

In Vitro

RMC-0331 has an IC 50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥98%

이름과 식별자

• 정식 스마일: CC(C1=CC(=CC(=C1)N)C(F)(F)F)NC2=NC(=NC3=C2CN(C3)C(=O)C4(CCOCC4)OC)Cl
• IUPAC Name: [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-(4-methoxyoxan-4-yl)methanone
• InChIKey: HOBOGRTXXDLZIB-GFCCVEGCSA-N
• INCHI: 1S/C22H25ClF3N5O3/c1-12(13-7-14(22(24,25)26)9-15(27)8-13)28-18-16-10-31(11-17(16)29-20(23)30-18)19(32)21(33-2)3-5-34-6-4-21/h7-9,12H,3-6,10-11,27H2,1-2H3,(H,28,29,30)/t12-/m1/s1
• PubChem CID: 155687064
• 분자량: 499.91

화학 및 물리적 특성

• 용해성: DMSO : 125 mg/mL (250.05 mM; Need ultrasonic)