Rosiptor - Moligand™, 10 mM in DMSO , CAS No.782487-28-9

CAS: 782487-28-9 Cat. No.: R1494221 분자식: C₂₀H₃₅NO₂ 분자량: 321.5 PubChem CID: 76965484

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. Rosiptor (AQX-1125) inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro .

Specifications

사양 및 순도

Moligand™, 10 mM in DMSO

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

등급

Moligand™

작업 유형

ACTIVATOR

제품 특성

• ALogP: 3

이름과 식별자

• 이성체 SMILES: C[C@@]1(CC[C@@H](C[C@@H]1CO)O)[C@H]2CC[C@]3([C@H]([C@@H]2CN)CCC3=C)C
• PubChem CID: 76965484
• 분자량: 321.5

참고 문헌

1. Li Gao, Junsheng Zhang, Tingting Yang, Ling Jiang, Xueqi Liu, Sheng Wang, Xian Wang, Yuebo Huang, Huaying Wang, Mengya Zhang, Tingting Gong, Lijuan Ma, Chao Li, Chaoyong He, Xiao-ming Meng, Yonggui Wu.  (2023)  STING/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease.  MOLECULAR THERAPY,      [PMID:37533255] [10.1016/j.ymthe.2023.07.026]

2. Fangyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, Wei Yi.  (2024)  Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:39705161] [10.1021/acs.jmedchem.4c02803]

3. Zheng Xiao, Peng Luo, Guoli Li, Huifang Tan, Chen Zhou, Dong Zeng, Yinyin Chen, Ying Li.  (2025)  HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.  JOURNAL OF NANOBIOTECHNOLOGY,      [PMID:41390419] [10.1186/s12951-025-03927-5]