Rovanersen - ≥94% , CAS No.2072901-32-5

CAS: 2072901-32-5 Cat. No.: R649836 분자량: 6617.00

등급 & 순도 ≥94%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can be used for huntington’s disease research.

In Vitro

In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

사양

사양 및 순도

≥94%

생화학 및 생리적 메커니즘

Rovanersen (WVE-120101) is an antisense oligonucleotide that specifically targets mutated mRNA copies of the huntington (HTT) gene without affecting healthy mRNA of HTT gene, thereby preventing the production of faulty Huntingtin protein. Rovanersen can b

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥94%

이름과 식별자

정식 스마일

[Rovanersen]

분자량

6617.00

화학 및 물리적 특성

• 용해성: H2O : ≥ 50 mg/mL (7.56 mM)

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥94% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2072901-32-5, and the molecular weight is 6617.00 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.