Ruscogenin - Moligand™, ≥98% , CAS No.472-11-7

CAS: 472-11-7 Cat. No.: R341641 분자식: C₂₇H₄₂O₄ 분자량: 430.62 EC 번호: 207-447-2 PubChem CID: 441893

GRADE & PURITY Moligand™, ≥98%

Synonyms

Ruscogenin, >=98% (HPLC) | RUSCOGENIN [MART.] | EINECS 207-447-2 | Ruscogenin | S9183 | CCG-269015 | BXI92R2VUJ | C08909 | RUSCOGENIN [INCI] | Z2037319104 | (25R)-Spirost-5-ene-1beta,3beta-diol | Q27108184 | (25R)-SPIROST-5-ENE-1.BETA.,3.BETA.-DIOL | 5-Ch

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Product Describtion:

Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, attenuates cerebral ischemia-induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway and exerts significant anti-inflammatory and anti-thrombotic activities.

Specifications

동의어

Ruscogenin, >=98% (HPLC) | RUSCOGENIN [MART.] | EINECS 207-447-2 | Ruscogenin | S9183 | CCG-269015 | BXI92R2VUJ | C08909 | RUSCOGENIN [INCI] | Z2037319104 | (25R)-Spirost-5-ene-1beta,3beta-diol | Q27108184 | (25R)-SPIROST-5-ENE-1.BETA.,3.BETA.-DIOL | 5-Ch

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

Ruscogenin inhibits the expressions of TF, iNOS, and NF-kappaB p65 and is therefore a potential target for acute lung injury or sepsis.

보관 조건

Protected from light,Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

순수함

≥98%

이름과 식별자

• Pubchem Sid: 504758772
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504758772
• 정식 스마일: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)O)C)C)C)OC1
• IUPAC Name: (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
• InChIKey: QMQIQBOGXYYATH-IDABPMKMSA-N
• INCHI: 1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
• 이성체 SMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5([C@@H](C[C@@H](C6)O)O)C)C)C)OC1
• PubChem CID: 441893
• 분자량: 430.62

관련 대상(인간)

BXPC-3 (2997 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

작용 메커니즘

화학 및 물리적 특성

• 용해성: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml
• 감도: Light sensitive
• 분자량: 430.600 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 430.308 Da
• Monoisotopic Mass: 430.308 Da
• Topological Polar Surface Area: 58.900 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 779.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 12
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1