Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 18 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
(S)-Donepezil is a S-enantiomer of Donepezil. Donepezil is a specific and potent AChE inhibitor .
| Isomeric SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC |
|---|---|
| Molecular Weight | 379.49 |
| Reaxy-Rn | 7081955 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7081955&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 206.72° C |
|---|
| 1. Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong, Zeng Li. (2023) Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease. Pharmaceuticals, 16 (10): (1468). [PMID:37895939] [10.3390/ph16101468] |
| 2. Xue Wang, Xiaomei Fu, Xiurong Luo, Yiyi Lai, Chuipu Cai, Yanfang Liao, Zhao Dai, Shuhuan Fang, Jiansong Fang. (2023) Network Proximity Analysis Deciphers the Pharmacological Mechanism of Osthole against D-Galactose Induced Cognitive Disorder in Rats. MOLECULES, 29 (1): (21). [PMID:38202603] [10.3390/molecules29010021] |
| 3. Rong Wei, Jun-Qiu He, Wen-Hua Chen, Kin Yip Tam. (2023) Evaluations of the neuroprotective effects of a dual-target isoquinoline inhibitor in the triple transgenic mouse model of Alzheimer's disease. NEUROSCIENCE LETTERS, [PMID:36889377] [10.1016/j.neulet.2023.137166] |
| 4. Wang Yue, Wu Xinyan, Yang Kailin, Liu Qing, Jiang Baoping, Yang Runmei, Xiao Peigen, He Chunnian. (2022) Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment. Frontiers in Pharmacology, [PMID:36034803] [10.3389/fphar.2022.952876] |
| 5. Yaojun Ju, Harapriya Chakravarty, Kin Yip Tam. (2020) An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer’s Disease. ACS Chemical Neuroscience, [PMID:33001625] [10.1021/acschemneuro.0c00464] |
| 6. Zhishen Xie, Jianping Zhao, Hui Wang, Yali Jiang, Qiaoling Yang, Yu Fu, Huahui Zeng, Christian Hölscher, Jiangyan Xu, Zhenqiang Zhang. (2020) Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ. BIOMEDICINE & PHARMACOTHERAPY, [PMID:32000045] [10.1016/j.biopha.2020.109886] |
| 7. Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejima. (2019) Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis. PHYSIOLOGY & BEHAVIOR, [PMID:31669775] [10.1016/j.physbeh.2019.112689] |
| 8. Yeheng Zhou, Wei Sun, Jiale Peng, Hui Yan, Li Zhang, Xingyong Liu, Zhili Zuo. (2019) Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. BIOORGANIC CHEMISTRY, [PMID:31585263] [10.1016/j.bioorg.2019.103322] |
| 9. Song Xiaoyu, Liu Bo, Cui Lingyu, Zhou Biao, Liu Lu, Liu Weiwei, Yao Guodong, Xia Mingyu, Hayashi Toshihiko, Hattori Shunji, Ushiki-Kaku Yuko, Tashiro Shin-ichi, Ikejima Takashi. (2018) Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1–42-Treated Rats. NEUROCHEMICAL RESEARCH, 43 (4): (796-805). [PMID:29397533] [10.1007/s11064-018-2481-3] |
| 10. Song Xiaoyu, Zhou Biao, Cui Lingyu, Lei Di, Zhang Pingping, Yao Guodong, Xia Mingyu, Hayashi Toshihiko, Hattori Shunji, Ushiki-Kaku Yuko, Tashiro Shin-ichi, Onodera Satoshi, Ikejima Takashi. (2016) Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress. NEUROCHEMICAL RESEARCH, 42 (4): (1073-1083). [PMID:28004303] [10.1007/s11064-016-2141-4] |
| 11. Bao-Yuan Hou. (2012) Ameliorative Effects of Curculigoside from Curculigo orchioides Gaertn on Learning and Memory in Aged Rats. MOLECULES, 17 (9): (10108-10118). [PMID:22922281] [10.3390/molecules170910108] |
| 12. Li Ming-Jie, Xu Jing-Yi, Zhang Hua-Yue, Guo Min, Lan Meng-Ning, Kong Jie, Liu Shi-Wei, Zheng Hua-Jun. (2024) A medicine and food homology formula prevents cognitive deficits by inhibiting neuroinflammation and oxidative stress via activating AEA–Trpv1–Nrf2 pathway. INFLAMMOPHARMACOLOGY, [PMID:39305407] [10.1007/s10787-024-01570-4] |
| 13. Zhang Jinpeng, Cui Xinyuan, Zhao Shuo, Chang Zenghui, Zhang Junshuo, Chen Yufeng, Liu Jiale, Sun Guohao, Wang Yiyuan, Liu Yuanyuan. (2024) Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry. Frontiers in Pharmacology, [PMID:38529184] [10.3389/fphar.2024.1342121] |
| 14. Lv Jie, He Chengcai, Cao Jingcheng, Shuai Qiuyan, Liu Xifang, Li Meng, Lin Yulong. (2024) Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:39733176] [10.1007/s00216-024-05712-z] |
| 15. Lu Yang, Zijin Lin, Ruijing Mu, Wenhan Wu, Hao Zhi, Xiaodong Liu, Hanyu Yang, Li Liu. (2024) Neurons enhance blood–brain barrier function via upregulating claudin-5 and VE-cadherin expression due to glial cell line-derived neurotrophic factor secretion. eLife, [PMID:39475379] [10.7554/eLife.96161] |
| 16. He Junqiu, Sun Shan, Wang Hongfeng, Ying Zheng, Tam Kin Yip. (2025) Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3β to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer’s Disease. Neuroscience Bulletin, [PMID:39907971] [10.1007/s12264-025-01354-y] |
| 17. Yirui Hong, Xinyu Zhang, Wenni Rong, Chenwei Hu, Yujie Jiang, Jiayi Xu, Huimin Wen, Fangjian Feng, C. Benjamin Naman, Haowei Shen, Shan He, Lijian Ding, Wei Cui. (2025) Uncovering the therapeutic potentials of marine-derived natural compounds with small amounts for neurological disorders. GENE, [PMID:40189165] [10.1016/j.gene.2025.149465] |
| 18. Xinyuan Cui, Zhaoqi Ding, Yujie Ji, Xinyi Wang, Yibing Wang, Zeyang Yuan, Yichun Zhang, Kai Liu, Yuanyuan Liu. (2025) The combination of gut microbiota and metabolomics reveals the effects of polysaccharides from Schisandra chinensis on microbiota and metabolic profile in Alzheimer's disease rats. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:41334604] [10.1002/jsfa.70361] |
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