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· · COA & SDS 모든 제품에 대한 사용 가능 · 주식 상품에 대한 같은 날 배송 S3I-201 - ≥96% , CAS No.501919-59-1
Synonyms
NSC 74859 | AKOS016366328 | Q-103549 | SCHEMBL4456216 | 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid | CHEBI:91224 | S31-201 | AC-32045 | EX-A342 | S3I201 | s-3i-201 | S3I-201 | MLS002701911 | GLG-302 | S3I 201 | JG1E8503OI | NCGC0
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
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이 등급을 선택하는 이유 ≥96% 최소한의 기준선 간섭이 필요한 민감한 크로마토그래피 및 분석 워크플로우용.
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보관 및 배송 Store at -20°C,Argon charged Ice chest + Ice pads 출고. 정확한 사양은 로트별 COA를 확인하세요.
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품질 문서 SDS, COA, 데이터시트, 사양서를 다운로드할 수 있습니다. 로트별 COA는 로트 번호 조회를 통해 확인할 수 있습니다.
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문헌적 근거 크로마토그래피, 유기 합성 및 교차 커플링 반응 분야의 동료 심사 논문 0편에서 인용되었습니다.
개요 S3I-201 (NSC 74859) effectively inhibits the DNA binding activity of STAT3 with IC50 of 86 μM, but has low inhibitory activity on STAT1 and STAT5.
S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.
사양 동의어
NSC 74859 | AKOS016366328 | Q-103549 | SCHEMBL4456216 | 2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid | CHEBI:91224 | S31-201 | AC-32045 | EX-A342 | S3I201 | s-3i-201 | S3I-201 | MLS002701911 | GLG-302 | S3I 201 | JG1E8503OI | NCGC0
생화학 및 생리적 메커니즘
NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ±33μM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently
보관 조건
Store at -20°C,Argon charged
배송
Ice chest + Ice pads
이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.
참고
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
이름과 식별자 Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/504758127
정식 스마일
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
IUPAC Name
2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
InChIKey
HWNUSGNZBAISFM-UHFFFAOYSA-N
INCHI
1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
이성체 SMILES
CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
문서 📋 안전 데이터 시트(SDS) 위험성, 취급, 보관 및 규제 준수를 포괄하는 종합 문서.
<<<<<<< HEAD
SDS 다운로드 → =======
SDS 다운로드 → >>>>>>> release248-p3
✅ 분석 성적서(COA) 로트별 품질 데이터. 로트 번호를 입력하여 정확한 COA를 확인하세요.
COA 조회 →
고급 데이터 Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids 분류 Benzene and substituted derivatives Subclass Benzoic acids and derivatives Intermediate Tree Nodes Not available Direct Parent Acylaminobenzoic acid and derivatives Alternative Parents p-Methylbenzenesulfonates Benzenesulfonate esters Tosyl compounds Salicylic acids Anilides Arylsulfonic acids and derivatives Benzenesulfonyl compounds Benzoic acids N-arylamides Benzoyl derivatives 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Organosulfonic acid esters Vinylogous acids Sulfonyls Secondary carboxylic acid amides Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds Organopnictogen compounds Molecular Framework Aromatic homomonocyclic compounds Substituents Acylaminobenzoic acid or derivatives - P-methylbenzenesulfonate - Benzenesulfonate ester - Salicylic acid - Benzenesulfonate - Tosyl compound - Salicylic acid or derivatives - Hydroxybenzoic acid - Arylsulfonic acid or derivatives - Benzoic acid - Anilide - Benzenesulfonyl group - N-arylamide - Benzoyl - Toluene - 1-hydroxy-4-unsubstituted benzenoid - Phenol - 1-hydroxy-2-unsubstituted benzenoid - Organosulfonic acid ester - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Sulfonyl - Vinylogous acid - Secondary carboxylic acid amide - Carboxamide group - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Carbonyl group - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Aromatic homomonocyclic compound 설명 This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 용해성 DMSO 73 mg/mL Water <1 mg/mL Ethanol <1 mg/mL 감도 Moisture sensitive 분자량 365.400 g/mol XLogP3 3.000 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 6 Exact Mass 365.057 Da Monoisotopic Mass 365.057 Da Topological Polar Surface Area 138.000 Ų Heavy Atom Count 25 Formal Charge 0 Complexity 578.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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