Sarolaner - 10mM in DMSO , CAS No.1398609-39-6

CAS: 1398609-39-6 Cat. No.: S655091 분자식: C₂₃H₁₈Cl₂F₄N₂O₅S 분자량: 581.36 EC 번호: 806-747-6 PubChem CID: 73169092

등급 & 순도 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide . Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC 80 value of 0.3 μg/mL against C. felis and a LC 100 value of 0.003 μg/mL against O. turicata

In Vitro

Sarolaner (450 nM-1 mM; 5 min) inhibits CfRDL-A285 and CfRDL-S285 receptors with γ-Aminobutyric acid (GABA)-induced currents. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: CHO-K1 cell lines Concentration: 450 nM-1 mM Incubation Time: 5 min Result: Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC 50 s of 135 and 136 nM, respectively.

In Vivo

Sarolaner (2.5 mg/kg; p.o. once) shows 100% efficacious against R. sanguineus and D. reticulatus . Sarolaner (1.25- 5 mg/kg; p.o. once) effectively against I. ricinus . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Dog infested with R. sanguineus and D. reticulatus Dosage: 2.5 mg/kg Administration: Oral gavage; 2.5 mg/kg once Result: Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus . Animal Model: Dog infested with I. ricinus Dosage: 1.25, 2.5 and 5 mg/kg Administration: Oral gavage; 1.25, 2.5 and 5 mg/kg once Result: Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.

IC50& Target:LC80: 0.3μg/mL ( C. felis ), LC100: 0.003 μg/mL ( O. turicata ), IC50: 135 nM (CfRDL-A285), 136 nM (CfRDL-S285)

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide . Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC 80 value of 0.3 μg/mL against C. felis and a LC 100 value of 0.003 μg/mL

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CS(=O)(=O)CC(=O)N1CC2(C1)C3=C(CO2)C=C(C=C3)C4=NO[C@@](C4)(C5=CC(=C(C(=C5)Cl)F)Cl)C(F)(F)F

PubChem CID

73169092

분자량

581.36

자주 묻는 질문

How should this product be stored?

Store at ?80 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1398609-39-6, the molecular formula is C23H18Cl2F4N2O5S, and the molecular weight is 581.36 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.