10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
SC79 SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.
In vitro
SC79 suppresses PHAKTM-GFP plasma membrane translocation, and enhances phosphorylation of all three Akt isoforms in HEK293, HeLa, HL60, NB4, and HsSulton (B cells) cells. SC79 reduces neuronal excitotoxicity and prevents stroke-induced neuronal death. SC79 restores proliferation of BRAT1 knockdown cells, and reduces the production of superoxide in mitochondria of MitoSox positive cells.
In vivo
In the permanent focal cerebral ischemia mouse model, SC79 (0.04 mg/g, i.p.) enables the cytosolic activation of Akt, and recapitulates the primary cellular function of Akt signaling, resulting in augmented neuronal survival.
Cell Data
cell lines：
Concentrations：8 μg/mL
Incubation Time：24 h
Powder Purity:
| 이성체 SMILES | CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Cl)N |
|---|---|
| PubChem CID | 2810830 |
| 분자량 | 364.8 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin. (2024) Bitter acids from Humulus lupulus L. alleviate D-galactose induced osteoblastic senescence and bone loss via regulating AKT/mTOR-mediated autophagy. JOURNAL OF FOOD AND DRUG ANALYSIS, 32 (4): (506). [PMID:39752859] [10.38212/2224-6614.3508] |
| 2. Zhuang Cuicui, Zhang Ruoqing, Bai Jiangang, Zhang Xinying, Zhao Jinhui. (2024) Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF-κB-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells. ARCHIVES OF MICROBIOLOGY, 206 (6): (1-11). [PMID:38713385] [10.1007/s00203-024-03971-z] |
