SEN177 - 10mM in DMSO , CAS No.2117405-13-5

CAS: 2117405-13-5 Cat. No.: S655452 분자식: C₁₈H₁₉FN₆ 분자량: 338.38 EC 번호: 821-054-9 PubChem CID: 91618245

등급 & 순도 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligomerisation and reduces the percentage of neurons with Q80 aggregates. SEN177 has the potential for Huntington’s disease research.

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

SEN177 is a potent glutaminyl cyclase (QPCT) inhibitor with an IC 50 of 0.013μM for glutaminyl-peptide cyclotransferase-like (QPCTL). SEN177 has a K i of 20 nM for human glutaminyl cyclase (hQC). SEN177 greatly reduces the early stages of mutant HTT oligo

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CN1C=NN=C1C2CCN(CC2)C3=C(C=CC=N3)C4=CN=C(C=C4)F

대체 CAS

2117405-13-5

PubChem CID

91618245

분자량

338.38

관련 대상(인간)

QPCT Tchem Glutaminyl-peptide cyclotransferase (1 Activities)

Discover Target: QPCT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)