SI-109 - ≥99% , CAS No.2429877-30-3

CAS: 2429877-30-3 Cat. No.: S647472 분자식: C₄₀H₄₄F₂N₇O₉P 분자량: 835.79

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

개요

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36

In Vitro

SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC 50 =3 μM). SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:STAT3 9 nM (Ki)

Specifications

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

SI-109 is a potent STAT3 SH2 domain inhibitor ( K i =9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 ( IC 50 =3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 de

보관 조건

Store at -20°C,Argon charged

배송

Ice chest + Ice pads

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순수함

≥99%

이름과 식별자

• 분자량: 835.79

화학 및 물리적 특성

• 용해성: DMSO : 150 mg/mL (179.47 mM; Need ultrasonic)