SIS3 free base - 10mM in DMSO , CAS No.521985-36-4

CAS: 521985-36-4 Cat. No.: S655157 분자식: C₂₈H₂₇N₃O₃ 분자량: 453.53 PubChem CID: 10138988

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 . SIS3 free base does not affect the phosphorylation of Smad2

In Vitro

SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Human dermal fibroblasts Concentration: 0.3, 1, 3, 10 μM Incubation Time: For 1 hour Result: Attenuated the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.

IC50& Target:Smad3, ALK-5

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 . SIS3 free base does not affect the phosphorylation of Smad2.

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

이성체 SMILES

CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5

PubChem CID

10138988

분자량

453.53