SJFα - 10mM in DMSO , CAS No.2254609-27-1

CAS: 2254609-27-1 Cat. No.: S655408 분자식: C₅₉H₆₇F₂N₇O₁₁S 분자량: 1120.27

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC 50 of 7.16  nM, but is far less effective at degrading p38δ (DC 50 =299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM

IC50& Target:p38α 7.16 nM (DC 50 ) p38δ 299 nM (DC 50 ) VHL

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC 50 of 7.16u2009u2009nM, but is far less effective at degrading p38δ (DC 50 =299u2009nM) and does not degrade the other p38 isoforms (β and γ) at concentrations

보관 조건

Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 분자량: 1120.27

자주 묻는 질문

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2254609-27-1, the molecular formula is C59H67F2N7O11S, and the molecular weight is 1120.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.