SLF TFA - 10mM in DMSO , CAS No.2378802-47-0

CAS: 2378802-47-0 Cat. No.: S655339 분자식: C₃₂H₄₁F₃N₂O₈ 분자량: 638.67

등급 & 순도 10mM in DMSO

Storage

Protected from light,Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC .

In Vitro

Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

사양

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC 50 of 2.6 μM for FKBP12 . SLF TFA can be used in the synthesis of PROTAC.

보관 조건

Protected from light,Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

분자량

638.67

자주 묻는 질문

How should this product be stored?

Store at ?80 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2378802-47-0, the molecular formula is C32H41F3N2O8, and the molecular weight is 638.67 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.