Stauprimide - ≥99% , CAS No.154589-96-5

CAS: 154589-96-5 Cat. No.: S139814 분자식: C₃₅H₂₈N₄O₅ 분자량: 584.62 PubChem CID: 46245328

GRADE & PURITY ≥99%

Synonyms

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide
An indolocarbazole promoter of embryonic stem cell differentiation.

Specifications

동의어

Q7604751 | [9S-(9alpha,10beta,11beta,13alpha)]-N-(2,3,10,11,12,1 3-Hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epo xy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j] [1,7]benzodiazonin-11-yl)-N-methylbenzamide | HY-N6747 | N-((9S,10R,11R,13R)-2,3,10,1

사양 및 순도

≥99%

생화학 및 생리적 메커니즘

Small molecule that primes embryonic stem cells (ESCs) for differentiation. Interacts with NME2 and inhibits its nuclear translocation. Increases the efficiency of directed differentiation of mouse and human ESCsin vitro.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥99%

이름과 식별자

Pubchem Sid

528767304

정식 스마일

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

IUPAC Name

N-[(2S,3R,4R,6R)-3-methoxy-2-methyl-16,18-dioxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-4-yl]-N-methylbenzamide

InChIKey

MQCCJEYZKWZQHU-MPRCCEKMSA-N

INCHI

1S/C35H28N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31H,17H2,1-3H3,(H,36,40,41)/t23-,24-,31-,35+/m1/s1

이성체 SMILES

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)C(=O)NC6=O)N(C)C(=O)C9=CC=CC=C9)OC

WGK 독일

3

PubChem CID

46245328

분자량

584.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • 분류 Indoles and derivatives
      • Subclass Carbazoles
        • Level5 Pyrrolocarbazoles
          • Level6 Indolocarbazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• 분류: Indoles and derivatives
• Subclass: Carbazoles
• Intermediate Tree Nodes: Pyrrolocarbazoles
• Direct Parent: Indolocarbazoles
• Alternative Parents: Pyrrolo[2,3-a]carbazoles Pyrroloindoles Phthalimides Benzamides Indoles Benzoyl derivatives Oxanes Tertiary carboxylic acid amides Pyrroles N-unsubstituted carboxylic acid imides Heteroaromatic compounds Tertiary amines Amino acids and derivatives Oxacyclic compounds Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - Phthalimide - Isoindolone - Benzamide - Benzoic acid or derivatives - Indole - Isoindoline - Isoindole or derivatives - Benzoyl - Monocyclic benzene moiety - Benzenoid - Oxane - Carboxylic acid imide - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxylic acid imide, n-unsubstituted - Pyrrole - Amino acid or derivatives - Carboxamide group - Tertiary amine - Azacycle - Oxacycle - Ether - Dialkyl ether - Carboxylic acid derivative - Amine - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• 설명: This compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

화학 및 물리적 특성

• 용해성: Soluble in DMSO}
• 감도: Light sensitive
• 녹는점(°C): 145°C
• 분자량: 584.600 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 584.206 Da
• Monoisotopic Mass: 584.206 Da
• Topological Polar Surface Area: 94.800 Ų
• Heavy Atom Count: 44
• Formal Charge: 0
• Complexity: 1220.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1