Stearoyl Ethanolamide - Moligand™, ≥98% , Agonist of GPR119, CAS No.111-57-9, Agonist of GPR119

CAS: 111-57-9 Cat. No.: S351349 분자식: C₂₀H₄₁NO₂ 분자량: 327.6 EC 번호: 203-883-2 PubChem CID: 27902

등급 & 순도 Moligand™, ≥98%

Synonyms

HMS3649H17 | N-(Hydroxyethyl)stearamide | 03XV449Q24 | N-octadecanoyl ethanolamine | GTPL3621 | Rewomid S 280 | SCHEMBL50178 | EINECS 203-883-2 | N-octadecanoylethanolamine | NSC52619 | NSC-52619 | octadecanoyl ethanolamide | Stearoyl-EA | STL454871 | EC

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Stearoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called anandamides. Stearoyl ethanolamide is the most prolific of several fatty acid ethanolamides produced by the PLD hydrolysis of murine neuroblastoma cell membrane phospholipids. The specific role of stearoyl ethanolamide in the cannabinergic system is still to be elucidated.

application：

Stearoyl ethanolamide (NSE) has been used as standard for quantifying in house synthesized NSE using thin layer chromatography.

사양

동의어

HMS3649H17 | N-(Hydroxyethyl)stearamide | 03XV449Q24 | N-octadecanoyl ethanolamine | GTPL3621 | Rewomid S 280 | SCHEMBL50178 | EINECS 203-883-2 | N-octadecanoylethanolamine | NSC52619 | NSC-52619 | octadecanoyl ethanolamide | Stearoyl-EA | STL454871 | EC

사양 및 순도

Moligand™, ≥98%

생화학 및 생리적 메커니즘

Most abundant fatty acid ethanolamide produced by PLD hydrolysis of cell membrane phospholipids.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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등급

Moligand™

작업 유형

AGONIST

작동 메커니즘

Agonist of GPR119

순수함

≥98%

제품 특성

Ki 데이터

Cannabinoid CB1 receptor: Ki= 217 nM (rat)

이름과 식별자

Pubchem Sid

488183063

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/488183063

정식 스마일

CCCCCCCCCCCCCCCCCC(=O)NCCO

IUPAC Name

N-(2-hydroxyethyl)octadecanamide

InChIKey

OTGQIQQTPXJQRG-UHFFFAOYSA-N

INCHI

1S/C20H41NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h22H,2-19H2,1H3,(H,21,23)

이성체 SMILES

CCCCCCCCCCCCCCCCCC(=O)NCCO

WGK 독일

3

PubChem CID

27902

분자량

327.6

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • 분류 Organonitrogen compounds
      • Subclass Amines
        • Level5 Alkanolamines
          • Level6 1,2-aminoalcohols
            • Level7 N-acylethanolamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• 분류: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Alkanolamines - 1,2-aminoalcohols
• Direct Parent: N-acylethanolamines
• Alternative Parents: N-acyl amines Secondary carboxylic acid amides Primary alcohols Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: N-acylethanolamine - Fatty amide - N-acyl-amine - Fatty acyl - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Alcohol - Organooxygen compound - Primary alcohol - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Carbonyl group - Aliphatic acyclic compound
• 설명: This compound belongs to the class of organic compounds known as n-acylethanolamines. These are compounds containing an N-acyethanolamine moiety, which is characterized by an acyl group is linked to the nitrogen atom of ethanolamine.
• External Descriptors: N-acyl ethanolamines (endocannabinoids)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

관련 대상(인간)

GPR119 Tclin Glucose-dependent insulinotropic receptor (0 Activities)

Discover Target: GPR119

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

Discover Target: CNR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

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U-251 (51189 Activities)

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786-0 (47912 Activities)

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NCI/ADR-RES (33767 Activities)

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HaCaT (4069 Activities)

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NCI-H460 (60772 Activities)

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관련 대상(비인간)

Faah Anandamide amidohydrolase (3907 Activities)

Discover Target: Faah

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Triticum aestivum (1582 Activities)

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Mus musculus (284745 Activities)

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Brassica napus (1186 Activities)

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Cucumis sativus (803 Activities)

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작용 메커니즘

화학 및 물리적 특성

• 용해성: Soluble in ethanol (~2 mg/ml), DMF (~2 mg/ml), DMSO (~100 μg/ml), water (>100 μg/ml at 25° C), and PBS (pH 7.2) (~100 μg/ml).
• 굴절률: n20D1.46 (Predicted)
• 끓는점(°C): ~486.0° C at 760 mmHg (Predicted)
• 녹는점(°C): 99-102° C (lit.)
• 분자량: 327.500 g/mol
• XLogP3: 7.300
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 18
• Exact Mass: 327.314 Da
• Monoisotopic Mass: 327.314 Da
• Topological Polar Surface Area: 49.300 Ų
• Heavy Atom Count: 23
• Formal Charge: 0
• Complexity: 244.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1