Super-TDU TFA - ≥98% , CAS No.1599441-71-0(free base)

CAS: 1599441-71-0(free base) Cat. No.: S414053 분자식: C₂₃₇H₃₆₉N₆₅O₇₀S(free base) 분자량: 5280.92(free base)

등급 & 순도 ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요

Targets

YAP/TEAD interaction

In vitro

Super-TDU reduced endogenous interaction between YAP and TEADs. It inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27, but not MKN-45. Moreover, the Super-TDU downregulated expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU significantly inhibited growth of HeLa, MGC-803, HCT116, A549, and MCF-7 cells, but only marginally inhibited growth of Jurkat and Raji cells, indicating a selectivity of the Super-TDU in inhibiting tumor cell growth. Super-TDU may specifically target tumor cells with an elevated YAP/VGLL4 ratio.

In vivo

Super-TDU has the potential in treating gastric cancer by directly targeting YAP-TEADs, and importantly, unlike the conventional drug compound 5-FU, its antitumor activity tends to be specific toward tumors with an elevated ratio of YAP to VGLL4.

Cell Research(from reference)

Cell lines：HCT116 and SW480 cells 

Concentrations：0-320 ng/ml 

Incubation Time：72 h 

사양

사양 및 순도

≥98%

생화학 및 생리적 메커니즘

Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

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순수함

≥98%

이름과 식별자

분자량

5280.92(free base)

화학 및 물리적 특성

• 용해성: Solubility (25°C) In vitro Water: 100 mg/mL (18.93 mM)
• 감도: Moisture Sensitive

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1599441-71-0(free base), the molecular formula is C237H369N65O70S(free base), and the molecular weight is 5280.92(free base) g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.