SUVN-911 - 10mM in DMSO , CAS No.2414674-71-6

CAS: 2414674-71-6 Cat. No.: S656387 분자식: C₁₁H₁₄Cl₂N₂O 분자량: 261.15 PubChem CID: 146026958

GRADE & PURITY 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

개요

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K i of 1.5 nM. SUVN-911 has antidepressant activity

In Vitro

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR. SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects . SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects . SUVN-911 shows metabolic stability in rats . SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Wistar rats (180-230 g) Dosage: 1 mg/kg, 3 mg/kg, 10.0 mg/kg Administration: Oral administration, daily, for 3 days Result: Showed antidepressant like activity with no signs of tachyphylaxis. Animal Model: Male Wistar rats (225 ± 25 g) Dosage: 3 mg/kg (Pharmacokinetic Analysis) Administration: Oral administration Result: AUC=3507 ng*h/mL, T 1/2 =3.34 hours.

IC50& Target:Ki: 1.5 nM (α4β2 receptor)

Specifications

사양 및 순도

10mM in DMSO

생화학 및 생리적 메커니즘

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K i of 1.5 nM. SUVN-911 has antidepressant activity.

보관 조건

Desiccated,Store at -80°C

배송

Dry ice packs + Cold packs

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이름과 식별자

• 이성체 SMILES: C1[C@H]2C[C@H]2N[C@@H]1COC3=CN=C(C=C3)Cl.Cl
• 대체 CAS: 2414674-71-6
• PubChem CID: 146026958
• 분자량: 261.15