T-5224(Cas No 530141-72-1) ≥97% high purity and research grade

Name: T-5224 - ≥97% , CAS No.530141-72-1
SKU: T414301
Availability: InStock

T-5224 - ≥97% , CAS No.530141-72-1

CAS: 530141-72-1 Cat. No.: T414301 분자식: C₂₉H₂₇NO₈ 분자량: 517.53 PubChem CID: 23626877

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T-5224 - ≥97% CAS No(530141-72-1) by Aladdin Scientific

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주문 가능

GRADE & PURITY ≥97%

Synonyms

3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid | DTXSID201026089 | AS-75034 | BDBM50044561 | T 5224;T5224 | 5-(4-(Cyclopentyloxy)-2-hydroxybenzoyl)-2-((2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)m

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

개요 Specifications 이름과 식별자 Documentation Advanced Data Taxonomic Classification 3D 구조 관련 대상(인간) 관련 대상(비인간) 작용 메커니즘 인증서(CoA, COO, BSE/TSE 및 분석 차트) 화학 및 물리적 특성 자주 묻는 질문과 기사 솔루션 계산기 리뷰 자주 묻는 질문

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Why this grade

≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

개요

Information

T-5224 T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β -induced up-regulation of Mmp-3 , Mmp-13 and Adamts-5 transcription.

Targets

c-Fos/AP-1 ; c-Jun ; IL-1β ; MMP-3 ; MMP-13 33441,

In vitro

T-5224 inhibits matrix-degrading MMPs and inflammatory cytokines including interleukin 1β. T-5224 reduces the amounts of inflammatory cytokines and MMPs in vitro in synovial cell and chondrocyte cultures.

In vivo

T-5224 is an inhibitor of c-Fos/activator protein-1 (AP-1) that prevents type II collagen–induced arthritis by reducing the amounts of inflammatory cytokines, MMPs and anti-tumor necrosis factor α in vivo in sera and joints.

Cell Research(from reference)

Cell lines：NIH/3T3, RAW264.7, human synovial sarcoma SW982 and human chondrosarcoma SW1353 cells

Concentrations：5.2 μM, 10 μM, 17 μM, 30 μM, 14 μM, 20 μM, 28 μM, 40 μM, 57 μM, 80 μM

Incubation Time：1 h

Specifications

동의어

사양 및 순도

≥97%

생화학 및 생리적 메커니즘

T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 t

보관 조건

Store at -20°C

배송

Ice chest + Ice pads

이 제품은 콜드 체인 배송이 필요합니다.지상 및 기타 경제 서비스는 사용할 수 없습니다.

순수함

≥97%

이름과 식별자

Pubchem Sid	504769439
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504769439
정식 스마일	C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O
IUPAC Name	3-[5-(4-cyclopentyloxy-2-hydroxybenzoyl)-2-[(3-oxo-1,2-benzoxazol-6-yl)methoxy]phenyl]propanoic acid
InChIKey	DALCQQSLNPLQFZ-UHFFFAOYSA-N
INCHI	1S/C29H27NO8/c31-24-15-21(37-20-3-1-2-4-20)8-10-22(24)28(34)19-6-11-25(18(14-19)7-12-27(32)33)36-16-17-5-9-23-26(13-17)38-30-29(23)35/h5-6,8-11,13-15,20,31H,1-4,7,12,16H2,(H,30,35)(H,32,33)
이성체 SMILES	C1CCC(C1)OC2=CC(=C(C=C2)C(=O)C3=CC(=C(C=C3)OCC4=CC5=C(C=C4)C(=O)NO5)CCC(=O)O)O
PubChem CID	23626877
분자량	517.53

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - 분류 Benzene and substituted derivatives
    - Subclass Benzophenones

Kingdom	Organic compounds
Superclass	Benzenoids
분류	Benzene and substituted derivatives
Subclass	Benzophenones
Intermediate Tree Nodes	Not available
Direct Parent	Benzophenones
Alternative Parents	Aryl-phenylketones Diphenylmethanes Phenylpropanoic acids Benzisoxazolones Phenoxy compounds Phenol ethers Benzoyl derivatives 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Alkyl aryl ethers Vinylogous acids Heteroaromatic compounds Isoxazoles Lactams Carboxylic acids Monocarboxylic acids and derivatives Azacyclic compounds Oxacyclic compounds Organic oxides Organonitrogen compounds Hydrocarbon derivatives Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzophenone - Aryl-phenylketone - Diphenylmethane - 3-phenylpropanoic-acid - Benzisoxazolone - Benzisoxazole - Phenoxy compound - Phenol ether - Benzoyl - Aryl ketone - Alkyl aryl ether - 1-hydroxy-4-unsubstituted benzenoid - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Azole - Heteroaromatic compound - Vinylogous acid - Isoxazole - Lactam - Ketone - Oxacycle - Carboxylic acid derivative - Carboxylic acid - Azacycle - Ether - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Carbonyl group - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
설명	This compound belongs to the class of organic compounds known as benzophenones. These are organic compounds containing a ketone attached to two phenyl groups.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D 구조

Lot Number	Certificate Type	날짜	항목
C2303554	Certificate of Analysis	Dec 12, 2025	T414301
C2303342	Certificate of Analysis	Sep 26, 2022	T414301
C2303343	Certificate of Analysis	Sep 26, 2022	T414301
C2303344	Certificate of Analysis	Sep 26, 2022	T414301
C2303515	Certificate of Analysis	Sep 26, 2022	T414301
C2303575	Certificate of Analysis	Sep 26, 2022	T414301
K2415037	Certificate of Analysis	Sep 26, 2022	T414301

용해성	Solubility (25°C) In vitro DMSO: 100 mg/mL (193.22 mM); Water: Insoluble; Ethanol: Insoluble;
분자량	517.500 g/mol
XLogP3	5.100
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	10
Exact Mass	517.174 Da
Monoisotopic Mass	517.174 Da
Topological Polar Surface Area	131.000 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	844.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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리뷰

자주 묻는 질문

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 530141-72-1, the molecular formula is C29H27NO8, and the molecular weight is 517.53 g/mol. InChIKey DALCQQSLNPLQFZ-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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